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Future Journal of Pharmaceutical Sciences

Table 1 Data for Hole board test

From: Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives

Sr no

Treatments

No of pocking

Duration of pocking (s)

Group I

Control

5.6 ± 0.50

11.40 ± 1.07

Group II

5a (50 mg/kg)

13.1 ± 2.34*

119.4 ± 3.41***

Group III

5b (50 mg/kg)

25.20 ± 1.28***

171.0 ± 3.92***

Group IV

5c (50 mg/kg)

19.40 ± 1.77***

157.2 ± 6.36***

Group V

5d (50 mg/kg)

12.8 ± 1.43*

136.8 ± 4.32***

Group VI

5e (50 mg/kg)

12.60 ± 0.92*

118.2 ± 2.43***

Group VII

5f (50 mg/kg)

19.80 ± 3.15***

166.2 ± 6.01***

Group VIII

Diazepam (4 mg/kg)

12.80 ± 0.86*

30.0 ± 1.39*

  1. Values are expressed as mean ± SEM, n = 5
  2. ns non significant
  3. *p < 0.05; ***p < 0.001
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