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Future Journal of Pharmaceutical Sciences

Table 2 Data for EPM test

From: Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives

Sr. no

Time spent (s)

No. of entries

Open arm

Close arm

Open arm

Close arm

Group 1

7.0 ± 2.09

104.6 ± 9.6

2.0 ± 0.44

19.5 ± 0.4

Group 2

118.2 ± 5.14***

43.20 ± 3.13***

10.80 ± 1.35***

10.8 ± 1.35***

Group 3

158.8 ± 4.04***

46.60 ± 4.33***

26.80 ± 0.86***

10.8 ± 1.15***

Group 4

138.0 ± 5.19***

45.20 ± 6.00***

21.80 ± 1.59***

11.8 ± 1.5***

Group 5

130.0 ± 5.64***

46.0 ± 2.42***

15.20 ± 1.4***

6.8 ± 0.96***

Group 6

134.2 ± 3.81***

41.20 ± 4.66***

14.60 ± 1.50***

9.2 ± 1.15***

Group 7

143.6 ± 4.47***

55.60 ± 2.33***

25.20 ± 0.58***

10.2 ± 1.06***

Group 8

34.20 ± 4.22***

60.5 ± 5.70***

9.00 ± 0.70***

12.10 ± 0.20***

  1. Values are expressed as mean ± SEM, n = 5.
  2. Test compounds Groups II–VII (5a–f) showed very highly significant anxiolytic activity (***p < 0.001)
  3. ns non significant
  4. ***p < 0.001
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