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Future Journal of Pharmaceutical Sciences

Table 3 Drug likeliness properties of derivatives

From: Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives

Comp

miLogP

Mol wt

TPSA

MR

HBA

HBD

5a

3.605

296.349

35.159

92.55

2

1

5b

3.091

310.376

35.159

96.80

3

1

5c

3.067

310.376

35.159

96.80

3

1

5d

3.043

310.376

35.159

96.80

3

1

5e

2.927

292.386

35.159

96.84

2

1

5f

3.581

296.349

35.159

92.55

2

1

  1. Comp compound, miLogP partition coefficient, Mol wt molecular weight, TPSA topological polar surface area, MR molar refractivity, HBA hydrogen bond acceptor, HBD hydrogen bond donor
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