Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives

Future Journal of Pharmaceutical Sciences

Table 4 Pharmacokinetic properties of derivatives

Compound	GI abs	BBB permeation	Pgp substrate	CYP2C19 inhibitor	CYP3A4 inhibitor	Bioavailability score
5a	High	Yes	Yes	No	Yes	0.55
5b	High	Yes	Yes	No	Yes	0.55
5c	High	Yes	Yes	No	Yes	0.55
5d	High	Yes	Yes	No	Yes	0.55
5e	High	Yes	Yes	No	Yes	0.55
5f	High	Yes	Yes	No	Yes	0.55