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Table 1 Regression parameters and the results of determination of pure samples of PSE and LOR by the proposed methods

From: Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

Drug name PSE LOR
methods D0 (256.8 nm)(SS) DW IDW RD IAM D0 (280 nm)
(Direct measurement or CM)
D0 (250 nm)
(CM)
IAM
Rangea
(μg/mL)
180.00–1200.00 5.00–30.00
Regressions parameters  
 Slope 0.0009 0.0006 0.0006 0.0014 1.0010 0.0260 0.0278 0.9847
 Intercept 0.0028 0.0059 0.0184 0.01196 0.1560 0.0019 0.0031 0.0749
Correlation coefficientb (r) 0.9999 0.9999 0.9999 0.9999 1.0000 0.9999 0.9999 0.9999
Accuracy (mean ± SD) 99.59 ± 0.86 98.51 ± 0.42 99.42 ± 0.76 99.28 ± 0.83 100.04 ± 0.23 101.06 ± 0.49 100.55 ± 0.33 100.88 ± 0.27
Precision
(±%RSD)
 
 Repeatabilityc 0.931 0.508 0.602 0.372 0.142 0.490 0.511 0.518
 Inter-day precisiond 1.159 0.942 1.119 0.775 0.373 0.631 0.714 0.702
  1. aSix calibration points in (μg/mL), average of three experiments.
  2. br = √R2
  3. cIntra-day precision (n = 9), average of 3 different concentrations (200.00, 600.00, and 1000.00 μg/mL) for PSE and (10.00, 20.00, and 25.00 μg/mL) for LOR, repeated 3 times each within the same day
  4. dInter-day precision (n = 9), average of 3 different concentrations (200.00, 600.00, and 1000.00 μg/mL) for PSE and (10.00, 20.00, and 25.00 μg/mL) for LOR, repeated 3 times each on 3 successive days