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Future Journal of Pharmaceutical Sciences

Table 1 Regression parameters and the results of determination of pure samples of PSE and LOR by the proposed methods

From: Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

Drug name

PSE

LOR

methods

D0 (256.8 nm)(SS)

DW

IDW

RD

IAM

D0 (280 nm)

(Direct measurement or CM)

D0 (250 nm)

(CM)

IAM

Rangea

(μg/mL)

180.00–1200.00

5.00–30.00

Regressions parameters

 

 Slope

0.0009

0.0006

0.0006

0.0014

1.0010

0.0260

0.0278

0.9847

 Intercept

0.0028

0.0059

0.0184

0.01196

0.1560

0.0019

0.0031

0.0749

Correlation coefficientb (r)

0.9999

0.9999

0.9999

0.9999

1.0000

0.9999

0.9999

0.9999

Accuracy (mean ± SD)

99.59 ± 0.86

98.51 ± 0.42

99.42 ± 0.76

99.28 ± 0.83

100.04 ± 0.23

101.06 ± 0.49

100.55 ± 0.33

100.88 ± 0.27

Precision

(±%RSD)

 

 Repeatabilityc

0.931

0.508

0.602

0.372

0.142

0.490

0.511

0.518

 Inter-day precisiond

1.159

0.942

1.119

0.775

0.373

0.631

0.714

0.702

  1. aSix calibration points in (μg/mL), average of three experiments.
  2. br = √R2
  3. cIntra-day precision (n = 9), average of 3 different concentrations (200.00, 600.00, and 1000.00 μg/mL) for PSE and (10.00, 20.00, and 25.00 μg/mL) for LOR, repeated 3 times each within the same day
  4. dInter-day precision (n = 9), average of 3 different concentrations (200.00, 600.00, and 1000.00 μg/mL) for PSE and (10.00, 20.00, and 25.00 μg/mL) for LOR, repeated 3 times each on 3 successive days
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