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Table 2 Determination of PSE and LOR in the laboratory-prepared mixtures by the proposed spectrophotometric methods

From: Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

%Recoverya ± SD
LOR:PSE PSE LOR
Ratio Concentrations
(μg/mL)
IAM AC
(256.8 nm)
DW IDW RD D0 at 256.8 nmc (SS) IAM CM D0 at 280 nmd
D0 at 280 nm D0 at 250 nm
(1:24)b 10:240 99.43 99.52 100.07 99.83 100.26 101.23 100.58 101.28 99.75 100.20
(1:12) 15:180 99.18 100.57 100.14 99.79 100.13 100.54 100.78 99.24 100.31 100.12
(1:18) 10:180 99.70 99.87 100.12 100.31 100.10 100.34 100.55 100.67 100.07 100.20
(1:30) 20:600 101.15 99.69 99.41 100.09 99.99 101.03 100.64 101.35 100.35 100.84
(1:48) 5:240 99.92 100.76 100.00 100.07 100.02 100.43 99.75 100.77 100.65 99.25
Mean ± SD   99.88 ± 0.76 100.08 ± 0.55 99.95 ± 0.31 100.02 ± 0.21 100.10 ± 0.11 100.71 ± 0.39 100.46 ± 0.41 100.66 ± 0.85 100.23 ± 0.34 100.12 ± 0.57
  1. aAverage of three determinations
  2. bRatio of the cited drugs as in the dosage form
  3. cDirect measurement of PSE at 256.8 nm after spectrum subtraction of LOR
  4. dDirect measurement of LOR at 280 nm