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Table 3 Determination of the studied drugs in the tablet dosage form (Clarinase®) and the application of standard addition technique by the proposed methods

From: Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

 

PSE

LOR

IAM

AC

DW

IDW

RD

D0at 256.8 nmc (SS)

IAM

CM

D0at 280 nmd

At 280 nm

At 250 nm

Pharmaceutical dosage formb (found% ± SD)

100.55 ± 0.15

99.76 ± 0.16

99.40 ± 0.29

99.31 ± 0.16

100.08 ± 0.19

98.74 ± 0.41

99.98 ± 0.11

100.93 ± 0.30

100.32 ± 0.05

100.00 ± 0.21

Standard Additiona (recovery% ± SD)

99.91 ± 1.07

99.47 ± 1.27

99.96 ± 0.96

100.19 ± 0.71

100.31 ± 0.68

99.88 ± 0.44

100.37 ± 0.67

101.49 ± 0.54

100.34 ± 1.07

100.71 ± 0.96

  1. aAverage of five experiments (pure added equivalent to 120, 240, 360, 480, and 600 μg/ml of PSE and 5, 10, 15, 17.5, and 20 μg/ml of LOR)
  2. bAverage of three experiments
  3. cDirect measurement of PSE at 256.8 nm after spectrum subtraction of LOR
  4. dDirect measurement of LOR at 280 nm