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Table 3 Determination of the studied drugs in the tablet dosage form (Clarinase®) and the application of standard addition technique by the proposed methods

From: Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

  PSE LOR
IAM AC DW IDW RD D0at 256.8 nmc (SS) IAM CM D0at 280 nmd
At 280 nm At 250 nm
Pharmaceutical dosage formb (found% ± SD) 100.55 ± 0.15 99.76 ± 0.16 99.40 ± 0.29 99.31 ± 0.16 100.08 ± 0.19 98.74 ± 0.41 99.98 ± 0.11 100.93 ± 0.30 100.32 ± 0.05 100.00 ± 0.21
Standard Additiona (recovery% ± SD) 99.91 ± 1.07 99.47 ± 1.27 99.96 ± 0.96 100.19 ± 0.71 100.31 ± 0.68 99.88 ± 0.44 100.37 ± 0.67 101.49 ± 0.54 100.34 ± 1.07 100.71 ± 0.96
  1. aAverage of five experiments (pure added equivalent to 120, 240, 360, 480, and 600 μg/ml of PSE and 5, 10, 15, 17.5, and 20 μg/ml of LOR)
  2. bAverage of three experiments
  3. cDirect measurement of PSE at 256.8 nm after spectrum subtraction of LOR
  4. dDirect measurement of LOR at 280 nm