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Table 4 Statistical comparison of the results obtained by the proposed spectrophotometric methods and those obtained by the official ones for the determination of PSE and LOR in their pure powdered forms

From: Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

Parameters PSE LOR
D0 at 256.8 nm (SS) DW IDW RD IAM Official methoda D0
(280 nm)
(Direct measurement or CM)
D0 (250 nm)
(CM)
IAM Official methoda
Mean 100.07 100.12 100.09 99.64 99.72 99.53 100.10 99.82 99.98 100.06
SD 0.69 0.67 0.76 0.65 0.22 0.42 0.68 0.47 0.62 0.75
N 7 7 7 7 7 6 7 7 7 7
Variance 0.4761 0.4489 0.5776 0.4225 0.0484 0.1764 0.4624 0.2209 0.3844 0.5625
Student’s t testb 1.665 (2.201) 1.860 (2.201) 1.601 (2.201) 0.355 (2.201) 1.046 (2.201)   0.104 (2.179) 0.717 (2.179) 0.217 (2.179)  
F testb 2.70 (4.95) 2.54 (4.95) 3.27 (4.95) 2.40(4.95) 3.64 (4.39)   1.22 (4.28) 2.55 (4.28) 1.46 (4.28)  
  1. aUSP methods for LOR is a HPLC method (using C18 column and mixture of dibasic potassium phosphate, methanol, and acetonitrile (7:6:6) as mobile phase with flow rate 1 mL/min), while for PSE is potentiometric titration method (using glacial acetic acid as a solvent and 0.1 N perchloric acid as a titrant) [38]
  2. bThe figures in parenthesis are the corresponding theoretical values at P = 0.05[47]