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Table 1 Regression parameters and validation sheet for the determination of pure samples of trimebutine maleate by the proposed UV-spectrophotometric methods

From: Different aspects in manipulating overlapped spectra used for the analysis of trimebutine maleate and structure elucidation of its degradation products

ParametersDWD2RDCC-SS
Rangea (μg/mL)5.00–60.00
LinearitySlope0.01870.01190.05890.0287
Intercept+ 0.0023+ 0.0029+ 0.0029− 0.0038
Correlation coefficient (r)b1.00001.00001.00001.0000
Mean ± SD99.97 ± 0.40100.36 ± 0.5899.90 ± 0.42100.15 ± 0.45
Accuracy (mean ± SD)99.90 ± 0.61100.96 ± 0.4699.74 ± 0.89100.74 ± 0.53
PrecisionRepeatabilityc0.3610.3480.6920.649
Intermediate precisiond0.8280.6990.8580.813
Specificity (mean ± SD)99.59 ± 0.19100.37 ± 0.5499.89 ± 0.5999.54 ± 052
  1. aSeven calibration points in μg/mL, average of three experiments
  2. br = √R2
  3. cRelative standard deviation (RSD)% average of three different concentrations repeated three times within the same day (10.00, 30.00, 50.00 μg/mL) = (intra-day precision)
  4. dRelative standard deviation (RSD)% average of three different concentrations repeated three times each on three successive days (10.00, 30.00, 50.00 μg/mL) = (inter-day precision)