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Table 5 Statistical comparison between the obtained results of the analysis of Gast-reg® 100 mg tablets (Batch No. 144695) by the proposed UV-spectrophotometric method and the reported method

From: Different aspects in manipulating overlapped spectra used for the analysis of trimebutine maleate and structure elucidation of its degradation products

Parameters

DW

D2

RD

CC-SS

Reported method [11]**

Mean

95.02

93.68

95.11

97.07

97.16

± SD

0.83

0.52

0.44

0.76

0.68

n

3

3

3

3

4

Variance

0.6889

0.2704

0.1936

0.5776

0.4624

Student’s t test*

0.023 (2.571)*

0.001 (2.571)*

0.005 (2.571)*

0.879 (2.571)*

 

F test*

1.490 (6.466)*

1.71 (6.43)*

2.39 (6.43)*

1.249 (6.466)*

  1. *The figures in parenthesis are the corresponding theoretical values at p = 0.05
  2. **The reported method used is RP-HPLC for the estimation of trimebutine maleate in tablet dosage form using a mobile phase consisting of 0.02 M ammonium acetate and acetonitrile in a gradient program