Table 2 Composition of powder blends for the development of immediate release fexofenadine HCl and sustained release montelukast sodium tablet layer

Ingredients (mg)

F1

F2

F3

F4

F5

F6

F7

F8

F9

F10

F11

F12

F13

 Fexofenadine HCl

120

90

60

90

120

120

60

60

120

90

90

60

90

 Microcrystalline cellulose

15

15

15

15

15

15

15

15

15

15

15

15

15

 Lactose monohydrate

23

58

98

60.5

38

35.5

95.5

83

25.5

63

73

85.5

48

 Sodium starch glycolate

20

20

5

12.5

5

12.5

12.5

20

12.5

5

5

12.5

20

 Sodium bicarbonate

15

10

15

15

15

10

10

15

20

20

10

20

20

 Starch

5

5

5

5

5

5

5

5

5

5

5

5

5

 Magnesium stearate

2

2

2

2

2

2

2

2

2

2

2

2

2

 Total weight

200

200

200

200

200

200

200

200

200

200

200

200

200

Ingredients (mg)

M1

M2

M3

M4

M5

M6

M7

M8

M9

M10

M11

M12

M13

 Montelukast sodium

5

7.5

5

7.5

10

10

5

10

7.5

5

7.5

10

7.5

 Microcrystalline cellulose

15

15

15

15

15

15

15

15

15

15

15

15

15

 Lactose monohydrate

30.5

15

16.5

13

27.5

41.5

46.5

11.5

29

32.5

45

25.5

43

 HPMC E 5 LV

30

45

45

45

30

15

15

45

30

30

15

30

15

 PVP K-30

15

15

15

15

15

15

15

15

15

15

15

15

15

 Magnesium stearate

4

2

3

4

2

3

3

3

3

2

2

4

4

 Indigo carmine blue

0.5

0.5

0.5

0.5

0.5

0.5

0.5

0.5

0.5

0.5

0.5

0.5

0.5

 Total weight

100

100

100

100

100

100

100

100

100

100

100

100

100