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Table 4 Stability-indicating method UHPLC-MS/MS

From: Ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS) in practice: analysis of drugs and pharmaceutical formulations

Drug Acid degradation Base degradation Photo-degradation Oxidative degra. Detection Ref
Conditions 0.1 to 1 N 0.1 to 2 M Light H2O2 and KMnO4
Fluticasone Propionate 7 days (50 °C) 24 h Thioester, Carboxylic ester, alcohol, ketone, diol [147]
Duloxetine (50 °C) 24 h 7 days Ether,1-naphthol  
Amlodipine 24 h 24 h 1,4-dihydropyridine ring  
Moxonidine (0.5 M) HCl
80 min
2 M NaOH at 70 °C for 15 min 7 days at 80 °C H2O2 5 h Impurity-A and impurity-D [148]
Rivaroxaban (60 °C) 6–24 h (60 °C) 1–6 h 2–5 h (254 nm) Morpholinone moiety, oxazolidinone ring, chlorothiophene carbonyl. [149]
Ciprofloxacin,Moxifloxacin, Norfloxacin, Ofloxacin 105–113 day CP-1 - CP-6 and OP-1 - OP-6, NP-1 - NP-5 MP-1 and MP-10 [150]
Hexazinone Degussa P25 and the nano-TiO2. 40 min complete degradation Methylamine, triazinone, urea, carbon dioxide. [151]
Ciprofloxacin, Difloxacin, Lomefloxacin, Norfloxacin, and Ofloxacin KMnO4 in acidic pH (3–6) N-1 and N-4 piperazine atoms and 3- monohydroxylated products 3-hydroxy-5-oxo derivatives [152]
Ampicillin (60 °C) 4 h (60 °C) for 4 h 2-(acetamidomethyl)-5,5-dimethylthiazolidine-4-carboxylate 1, 1-dioxide [153]