Table 4 Stability-indicating method UHPLC-MS/MS
Drug | Acid degradation | Base degradation | Photo-degradation | Oxidative degra. | Detection | Ref |
|---|---|---|---|---|---|---|
Conditions | 0.1 to 1 N | 0.1 to 2 M | Light | H2O2 and KMnO4 | – | – |
Fluticasone Propionate | 7 days | (50 °C) 24 h | – | – | Thioester, Carboxylic ester, alcohol, ketone, diol | [147] |
Duloxetine | (50 °C) 24 h | 7 days | – | – | Ether,1-naphthol | |
Amlodipine | 24 h | 24 h | – | – | 1,4-dihydropyridine ring | |
Moxonidine | (0.5 M) HCl 80 min | 2 M NaOH at 70 °C for 15 min | 7 days at 80 °C | H2O2 5 h | Impurity-A and impurity-D | [148] |
Rivaroxaban | (60 °C) 6–24 h | (60 °C) 1–6 h | 2–5 h (254 nm) | – | Morpholinone moiety, oxazolidinone ring, chlorothiophene carbonyl. | [149] |
Ciprofloxacin,Moxifloxacin, Norfloxacin, Ofloxacin | – | – | 105–113 day | – | CP-1 - CP-6 and OP-1 - OP-6, NP-1 - NP-5 MP-1 and MP-10 | [150] |
Hexazinone | – | – | Degussa P25 and the nano-TiO2. 40 min complete degradation | – | Methylamine, triazinone, urea, carbon dioxide. | [151] |
Ciprofloxacin, Difloxacin, Lomefloxacin, Norfloxacin, and Ofloxacin | – | – | – | KMnO4 in acidic pH (3–6) | N-1 and N-4 piperazine atoms and 3- monohydroxylated products 3-hydroxy-5-oxo derivatives | [152] |
Ampicillin | (60 °C) 4 h | (60 °C) for 4 h | – | – | 2-(acetamidomethyl)-5,5-dimethylthiazolidine-4-carboxylate 1, 1-dioxide | [153] |