Formulation, in-vitro and in-vivo pharmacokinetic evaluation of simvastatin nanostructured lipid carrier loaded transdermal drug delivery system

Future Journal of Pharmaceutical Sciences

Table 2 Coefficient table for effect of independent variable on dependent variable

Response	Intercept	A	B	C	AB	AC	BC	A²	B²	C²
PS	199.28	245.612	− 0.2625	− 27.05	7.2	− 40.375	− 0.925	194.235	9.885	− 13.29
P =	199.28	< 0.0001	0.9842	0.0728	0.7031	0.0612	0.9607	< 0.0001	0.5933	0.4765
ZP	− 23.36	− 0.8	− 8.3375	− 1.1875	1.35	− 1.5	− 1.025	− 0.2575	− 0.4325	− 0.4825
P =	− 23.36	0.3245	< 0.0001	0.1598	0.2466	0.2029	0.3691	0.8117	0.6902	0.6570
EE	76.396	− 16.7975	− 0.1525	0.765	0.47	1.785	− 0.925	− 3.293	− 0.233	0.632
P =	76.396	< 0.0001	0.5976	0.0276	0.2674	0.0026	0.0495	< 0.0001	0.5594	0.1404