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Table 4 Effect of No. of balls & time on Saturation solubility and particle size distribution of co-crystal (n = 3, mean ± SD)

From: Particle engineering of fenofibrate for advanced drug delivery system

Batch No./ Runs

X1 (No. of balls) (….)

X2 (Time) (min.)

Saturation solubility (g/ml) (Y1)

Particle size(nm)±S.D (Y2)

FNOCC1

(+1) 9

30 (-1)

0.0603±0.02

1342.0±0.402

FNOCC2

(-1) 3

90 (+1)

0.1034±0.07

721.329±0.41

FNOCC3

(-1) 3

60 (0)

0.1969±0.08

453.459±0.23

FNOCC4

(0) 6

90 (+1)

0.0816±0.02

450.127±0.62

FNOCC5

(+1) 9

60 (0)

0.0703±0.01

443.189±0.603

FNOCC6

(+1) 9

90 (+1)

0.1142±0.05

974.665±0.512

FNOCC7

(-1) 3

30 (-1)

0.3874±0.32

221.231±0.456

FNOCC8

(0) 6

30 (-1)

0.1600±0.04

1371.818±0.510

FNOCC9

(0) 6

60 (0)

0.1206±0.03

1095.870±0.462