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Table 1 Variables in the Box–Behnken design

From: Application of Box–Behnken design and desirability function in the development and optimization of self-nanoemulsifying drug delivery system for enhanced dissolution of ezetimibe Independent variables Dependent variables Goal for dependent variables
1. Amount of oil added (X1) Globule size (Y1) Minimize
2. Amount of surfactant added (X2) Percentage transmittance (Y2) Maximize
3. Amount of co-surfactant added (X3) Self-emulsification time (Y3) Minimize
4. Dissolution after 5 minutes (Y4) Maximize
5. Dissolution after 40 minutes (Y5) Maximize