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Table 2 Design layout of Box–Behnken design batches for prepared SNEDDS

From: Application of Box–Behnken design and desirability function in the development and optimization of self-nanoemulsifying drug delivery system for enhanced dissolution of ezetimibe

Experimental run Coded factor levels
Factor 1 (X1) Factor 2 (X2) Factor 3 (X3)
1 0 0 0
2 0 1 − 1
3 1 − 1 0
4 0 − 1 − 1
5 0 0 0
6 1 0 − 1
7 1 0 1
8 − 1 1 0
9 1 1 0
10 − 1 0 − 1
11 0 0 0
12 − 1 0 1
13 0 1 1
14 0 − 1 1
15 − 1 − 1 0
Translation of coded levels in actual units  
Coded levels Low* Middle* High*
− 1 0 1
Factor 1 (X1)
(Amount of oil)
10% 40% 70%
Factor 2 (X2)
(Amount of surfactant)
20% 40% 60%
Factor 3 (X3)
(Amount of co-surfactant)
10% 20% 30%
  1. *Low, middle, and high-coded levels were chosen on the basis of preliminary trials conducted and pseudoternary diagrams constructed for efficient percentage transmittance.