Table 2 Design layout of Box–Behnken design batches for prepared SNEDDS
Experimental run | Coded factor levels | ||
Factor 1 (X1) | Factor 2 (X2) | Factor 3 (X3) | |
1 | 0 | 0 | 0 |
2 | 0 | 1 | − 1 |
3 | 1 | − 1 | 0 |
4 | 0 | − 1 | − 1 |
5 | 0 | 0 | 0 |
6 | 1 | 0 | − 1 |
7 | 1 | 0 | 1 |
8 | − 1 | 1 | 0 |
9 | 1 | 1 | 0 |
10 | − 1 | 0 | − 1 |
11 | 0 | 0 | 0 |
12 | − 1 | 0 | 1 |
13 | 0 | 1 | 1 |
14 | 0 | − 1 | 1 |
15 | − 1 | − 1 | 0 |
Translation of coded levels in actual units | |||
Coded levels | Low* | Middle* | High* |
− 1 | 0 | 1 | |
Factor 1 (X1) (Amount of oil) | 10% | 40% | 70% |
Factor 2 (X2) (Amount of surfactant) | 20% | 40% | 60% |
Factor 3 (X3) (Amount of co-surfactant) | 10% | 20% | 30% |