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Table 2 Melting point, solubility, and % drug content of co-crystals

From: Formulation and evaluation of buccal films of piroxicam co-crystals

Sr. no.Drug/co-formerMelting point of single entityCo-crystal melting point (1:1)Solubility (mg/100ml)% drug content
1Piroxicam206–208 °C10.73 ± 0.985
2Piroxicam-sucralose125 °C186 °C60.73 ± 1.9598.37
3Piroxicam-dioxane11.8 °C178 °C34.22 ± 3.5695.66
4Piroxicam-oxalic acid189 °C230 °C32.52 ± 2.2195.86
5Piroxicam-malonic acid135.6 °C165 °C42.84 ± 2.8296.30
6Piroxicam-caprylic acid16.7 °C186 °C38.20 ± 1.2198.96
7Piroxicam-fumaric acid287 °C194 °C37.62 ± 3.6197.93
8Piroxicam-adipic acid152 °C196 °C34.14 ± 4.5099.39
9Piroxicam-benzoic acid122 °C180 °C32.55 ± 2.4396.50
10Piroxicam-xylitol92 °C196 °C35.68 ± 7.8196.55