Table 3 Evaluation parameters of formulated films of piroxicam co-crystals
From: Formulation and evaluation of buccal films of piroxicam co-crystals
Parameters | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
Weight (mg) | 43.94 ± 5.69 | 48.44 ± 4.57 | 65.02 ± 8.73 | 46.74 ± 6.12 | 54.89 ± 4.16 | 68.45 ± 5.69 |
Thickness (mm) | 0.112 ± 0.04 | 0.148 ± 0.03 | 0.213 ± 0.03 | 0.138 ± 0.02 | 0.196 ± 0.05 | 0.235 ± 0.06 |
% Drug content | 94.88 ± 0.14 | 96.86 ± 0.08 | 94.94 ± 0.17 | 96.88 ± 0.08 | 94.88 ± 0.12 | 93.15 ± 2.90 |
% moisture uptake | 15.807 ± 6.85 | 9.633 ± 3.25 | 11.61 ± 2.32 | 12.6 ± 42 | 13.553 ± 3.9 | 12.89 ± 4.2 |
% moisture loss | 4.76 ± 2.38 | 5.29 ± 1.47 | 11.3 ± 0.86 | 8.27 ± 3.81 | 3.74 ± 2.38 | 5.96 ± 2.63 |
Surface pH | 6.61 ± 0.03 | 6.38 ± 0.07 | 6.82 ± 0.03 | 6.82 ± 0.06 | 6.76 ± 0.07 | 6.29 ± 0.07 |
Folding endurance | 256.33 ± 1.46 | 285.66 ± 2.08 | 290.10 ± 1.00 | 286.66 ± 2.56 | 296.66 ± 1.52 | 274.40 ± 2.00 |
Mucoadhesive strength (dyne/cm2) | 3760 ± 273 | 4685 ± 450 | 5033 ± 530 | 4828 ± 452 | 5034 ± 563 | 5617 ± 636 |
Tensile strength (kg/cm2) | 1.61 ± 0.01 | 1.57 ± 0.03 | 1.26 ± 0.01 | 1.61 ± 0.01 | 1.57 ± 0.031 | 1.26 ± 0.01 |
% Swelling index | 12.12 ± 1.24 | 14.33 ± 1.77 | 20.51 ± 1.58 | 16.77 ± 1.69 | 17.25 ± 1.43 | 23.04 ± 1.25 |