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Table 3 Evaluation parameters of formulated films of piroxicam co-crystals

From: Formulation and evaluation of buccal films of piroxicam co-crystals

ParametersF1F2F3F4F5F6
Weight (mg)43.94 ± 5.6948.44 ± 4.5765.02 ± 8.7346.74 ± 6.1254.89 ± 4.1668.45 ± 5.69
Thickness (mm)0.112 ± 0.040.148 ± 0.030.213 ± 0.030.138 ± 0.020.196 ± 0.050.235 ± 0.06
% Drug content94.88 ± 0.1496.86 ± 0.0894.94 ± 0.1796.88 ± 0.0894.88 ± 0.1293.15 ± 2.90
% moisture uptake15.807 ± 6.859.633 ± 3.2511.61 ± 2.3212.6 ± 4213.553 ± 3.912.89 ± 4.2
% moisture loss4.76 ± 2.385.29 ± 1.4711.3 ± 0.868.27 ± 3.813.74 ± 2.385.96 ± 2.63
Surface pH6.61 ± 0.036.38 ± 0.076.82 ± 0.036.82 ± 0.066.76 ± 0.076.29 ± 0.07
Folding endurance256.33 ± 1.46285.66 ± 2.08290.10 ± 1.00286.66 ± 2.56296.66 ± 1.52274.40 ± 2.00
Mucoadhesive strength (dyne/cm2)3760 ± 2734685 ± 4505033 ± 5304828 ± 4525034 ± 5635617 ± 636
Tensile strength (kg/cm2)1.61 ± 0.011.57 ± 0.031.26 ± 0.011.61 ± 0.011.57 ± 0.0311.26 ± 0.01
% Swelling index12.12 ± 1.2414.33 ± 1.7720.51 ± 1.5816.77 ± 1.6917.25 ± 1.4323.04 ± 1.25