Fig. 1

a Single cytotoxicity of Hst and Dox against 4T1 cells. b Combination cytotoxicity of Hst and Dox on 4T1 cells, and its combination index (CI) value. The 4T1 cells were grown in 96-well plates with a density of 2 × 10³ cells/well. The cells were incubated for 24 h and treated with a series of Hst, Dox, and their combination. Cell viability was determined by using the MTT assay, as described in the “Methods” section. Results are presented as mean ± SD (n = 3)