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Table 3 List of drugs formulated as solid/liquid self-micro emulsified drug delivery systems (SMEDDS)

From: Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery system (SEDDS)




Formualtion type

Therapeutic outcome




Cremophore RH40/transcutol

Supersaturatable self-emulsifying drug delivery system (S-SEDDS)

Enhanced oral bioavailability



Medium-chain triglyceride oil (Myritol 318),

TPGS (D-a-tocopheryl polyethylene glycol 1000 succinate) and polysorbate (Tween 80 or Tween 20)

Self-microemulsifying drug delivery system (SMEDDS)

Increased oral bioavailability


Rosuvastatin calcium

Capmul MCM

Cremophore ELP/Propylene Glycol

Solid self-emulsifying drug delivery system

Improved bioavailability



Corn oil, soybean oil, ethyl oleate, GTCC, IPM, castor oil, masine-1, olive oil, IPP

Labrafil M1944, Labrasol, OP-10/ Transcutol P

Solid self-microemulsifying dispersible tablets

Increased bioavailability


Alginate and curcuin

Cremophor EL, Larafac PG, Capryol 90

Labrasol, Sodium CMC (absorbent), Aerosil 200

Curcumin loaded solid SMEDDS designed by freeze-drying technique

Enhance the release profile of drug



Capryol 90

Cremophore EL/transcutol HP

Gelatin micropatrticles of a self-emulsified system

Enhanced oral bioavailability of dutasteride



Capryol 90

Cremophore EL/ Transcutol HP

Soluplus-based supersaturable self-emulsifying drug delivery system

Improved oral absorption of dutasteride



Caprylic/ Capric triglycerides

Polysorbate 80/cremophore-RH 40

Solid self-microemulsifying drug delivery systems

Improved drug release and increase bioavailability


ELQ – 331 (antimalarial prodrug)

Tween-20, Span® 85, PEG 400 and sodium lauryl sulfate

Tween-20, Span® 85, PEG 400 and sodium lauryl sulfate

Preparation of spray dried dispersions and its comparison

Described the effect on the solubility and bioavailability of prodrug



Capryol 90, Lauroglycol 90, Labrafac Hydro WL 1219, polyglyceryl-3 dioleate

Labrasol, Tween 20/glycofurol, transcutol, PEG 400

fast-dissolving solid self-microemulsifying tablets

Improve dissolution and technological properties



Imwitor 988

Cremophore EL and cremophore RH 40 (1:1)/capmul GMS K-50

Solid self-microemulsifying drug delivery system

Enhance dissolution and oral bioavailability of drug



Capryol 90

Kolliphor EL/transcutol P

Self-emulsifying drug delivery system

Improved drug release



Mygliol 812

Cremophor EL/macrogol 400

Solid self-microemulsifying drug delivery systems (S-SMEDDS)

Increase in dissolution rate compared to pure Carbamazepine



Miglyol 812

Gelucire 44/14

Tablets and mini-tablets of spray dried SMEDDS

Lowered dissolution profile of naproxen from tablets and minitablets



Oleic acid and capryol 90

Caprol MPGO, Kolliphor RH40, Labrasol and Tween 80/PEG 400 and 1,2-propylene glycol

Liquid and solid Self-Emulsifying Drug Delivery Systems

better solubilization properties exhibited by solid formulation



Isopropyl myristate

lecithin/D-a-tocopheryl polyethylene glycol succinate/ethanol

Spray-dried self-microemulsifying drug delivery systems

Enhanced the cytotoxic activity on lung cancer cells


Paprika Oleoresin (carotenoid)


Tween 80/ethanol

Solid self-microemulsifying system

Enhanced bioavailability and pigmentation



Miglyol 812

Gelucire 44/14/glycerin


Preserved the self- microemulsifying properties of liquid SMEDDS & exhibited dissolution profiles similar to liquid SMEDDS



Coconut oil and Isopropyl myristate

Tween 80/PEG 400 and glycerin

Solid self-micro emulsification system

Improve bioavailability


Mefanamic Acid

clove oil, olive oil and rice bran oil, Imwitor 742

Tween 60, cremophore El/transcutol HP

Self-emulsifying formulation

Enhance solubility


Atrovastatin calcium

Capmul® MCM

Tween® 20/tetraglycol

Solidified self-microemulsifying drug delivery system

Improve dissolution and bioavailability



Labrafil 2125 CS

Tween 20/maisine 35-1

Self-microemulsifying drug delivery System

Improve dissolution and bioavailability




Propylene glycol

Self-microemusifying drug delivery system

Enhancing bioavailability and lymphatic uptake of the drug



Caprylic acid, cremophor RH 40, cremophor EL

Tween 80 and PEG 200

Vaginal self-emulsifying delivery system

Enhancement of drug penetration


Cathepsin K inhibitor (HL235)

Capmul MCM EP

Tween 20 (surfactant) and 20.0% carbitol (cosurfactant)

SEDDS were prepared by applying D-optimal mixture design

Improve drug solubility and drug loading. Increase bioavailability


Ferulic acid

Glyceryl triacetate, OP-10, Labrasol combination

PEG 400

Preparation of SMEDDS for

Enhancement of oral solubility of drug with improved hypnotic activity


Kaempferol and quercetin from plant Moringa oliefera

CrodamolTM P C (propylene glycol dicaprylocaprate)

Tween® 80 and polyethylene glycol 400


Enhancement of solubility of the flavonoids



Capryol 90

Transcutol HP and Tween 80


Enhancement of solubility of the drug