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Table 3 List of drugs formulated as solid/liquid self-micro emulsified drug delivery systems (SMEDDS)

From: Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery system (SEDDS)

Drug Oils Surfactant/co-surfactant Formualtion type Therapeutic outcome Ref.
Silybin Labrafac Cremophore RH40/transcutol Supersaturatable self-emulsifying drug delivery system (S-SEDDS) Enhanced oral bioavailability [6]
Fenofibrate Medium-chain triglyceride oil (Myritol 318), TPGS (D-a-tocopheryl polyethylene glycol 1000 succinate) and polysorbate (Tween 80 or Tween 20) Self-microemulsifying drug delivery system (SMEDDS) Increased oral bioavailability [13]
Rosuvastatin calcium Capmul MCM Cremophore ELP/Propylene Glycol Solid self-emulsifying drug delivery system Improved bioavailability [19]
Celastrol Corn oil, soybean oil, ethyl oleate, GTCC, IPM, castor oil, masine-1, olive oil, IPP Labrafil M1944, Labrasol, OP-10/ Transcutol P Solid self-microemulsifying dispersible tablets Increased bioavailability [26]
Alginate and curcuin Cremophor EL, Larafac PG, Capryol 90 Labrasol, Sodium CMC (absorbent), Aerosil 200 Curcumin loaded solid SMEDDS designed by freeze-drying technique Enhance the release profile of drug [28]
Dutasteride Capryol 90 Cremophore EL/transcutol HP Gelatin micropatrticles of a self-emulsified system Enhanced oral bioavailability of dutasteride [34]
Dutasteride Capryol 90 Cremophore EL/ Transcutol HP Soluplus-based supersaturable self-emulsifying drug delivery system Improved oral absorption of dutasteride [35]
Carbamazepine Caprylic/ Capric triglycerides Polysorbate 80/cremophore-RH 40 Solid self-microemulsifying drug delivery systems Improved drug release and increase bioavailability [45]
ELQ – 331 (antimalarial prodrug) Tween-20, Span® 85, PEG 400 and sodium lauryl sulfate Tween-20, Span® 85, PEG 400 and sodium lauryl sulfate Preparation of spray dried dispersions and its comparison Described the effect on the solubility and bioavailability of prodrug [52]
Glyburide Capryol 90, Lauroglycol 90, Labrafac Hydro WL 1219, polyglyceryl-3 dioleate Labrasol, Tween 20/glycofurol, transcutol, PEG 400 fast-dissolving solid self-microemulsifying tablets Improve dissolution and technological properties [58]
Ritonavir Imwitor 988 Cremophore EL and cremophore RH 40 (1:1)/capmul GMS K-50 Solid self-microemulsifying drug delivery system Enhance dissolution and oral bioavailability of drug [67]
Simvastatin Capryol 90 Kolliphor EL/transcutol P Self-emulsifying drug delivery system Improved drug release [68]
Carbamazepine Mygliol 812 Cremophor EL/macrogol 400 Solid self-microemulsifying drug delivery systems (S-SMEDDS) Increase in dissolution rate compared to pure Carbamazepine [69]
Naproxen Miglyol 812 Gelucire 44/14 Tablets and mini-tablets of spray dried SMEDDS Lowered dissolution profile of naproxen from tablets and minitablets [70]
Atrovastatin Oleic acid and capryol 90 Caprol MPGO, Kolliphor RH40, Labrasol and Tween 80/PEG 400 and 1,2-propylene glycol Liquid and solid Self-Emulsifying Drug Delivery Systems better solubilization properties exhibited by solid formulation [71]
Atorvastatin Isopropyl myristate lecithin/D-a-tocopheryl polyethylene glycol succinate/ethanol Spray-dried self-microemulsifying drug delivery systems Enhanced the cytotoxic activity on lung cancer cells [72]
Paprika Oleoresin (carotenoid) Limonene Tween 80/ethanol Solid self-microemulsifying system Enhanced bioavailability and pigmentation [73]
Naproxen Miglyol 812 Gelucire 44/14/glycerin Solid SMEDDS Preserved the self- microemulsifying properties of liquid SMEDDS & exhibited dissolution profiles similar to liquid SMEDDS [74]
Atorvastatin Coconut oil and Isopropyl myristate Tween 80/PEG 400 and glycerin Solid self-micro emulsification system Improve bioavailability [75]
Mefanamic Acid clove oil, olive oil and rice bran oil, Imwitor 742 Tween 60, cremophore El/transcutol HP Self-emulsifying formulation Enhance solubility [76]
Atrovastatin calcium Capmul® MCM Tween® 20/tetraglycol Solidified self-microemulsifying drug delivery system Improve dissolution and bioavailability [77]
Mebendazole Labrafil 2125 CS Tween 20/maisine 35-1 Self-microemulsifying drug delivery System Improve dissolution and bioavailability [78]
Huperzin CremophorRH40 Propylene glycol Self-microemusifying drug delivery system Enhancing bioavailability and lymphatic uptake of the drug [79]
Curcumin Caprylic acid, cremophor RH 40, cremophor EL Tween 80 and PEG 200 Vaginal self-emulsifying delivery system Enhancement of drug penetration [80]
Cathepsin K inhibitor (HL235) Capmul MCM EP Tween 20 (surfactant) and 20.0% carbitol (cosurfactant) SEDDS were prepared by applying D-optimal mixture design Improve drug solubility and drug loading. Increase bioavailability [81]
Ferulic acid Glyceryl triacetate, OP-10, Labrasol combination PEG 400 Preparation of SMEDDS for Enhancement of oral solubility of drug with improved hypnotic activity [82]
Kaempferol and quercetin from plant Moringa oliefera CrodamolTM P C (propylene glycol dicaprylocaprate) Tween® 80 and polyethylene glycol 400 SMEDDS Enhancement of solubility of the flavonoids [83]
Nilotinib Capryol 90 Transcutol HP and Tween 80 SMEDDS Enhancement of solubility of the drug [84]