Table 3 List of drugs formulated as solid/liquid self-micro emulsified drug delivery systems (SMEDDS)

Silybin

Labrafac

Cremophore RH40/transcutol

Supersaturatable self-emulsifying drug delivery system (S-SEDDS)

Enhanced oral bioavailability

[6]

Fenofibrate

Medium-chain triglyceride oil (Myritol 318),

TPGS (D-a-tocopheryl polyethylene glycol 1000 succinate) and polysorbate (Tween 80 or Tween 20)

Self-microemulsifying drug delivery system (SMEDDS)

Increased oral bioavailability

[13]

Rosuvastatin calcium

Capmul MCM

Cremophore ELP/Propylene Glycol

Solid self-emulsifying drug delivery system

Improved bioavailability

[19]

Celastrol

Corn oil, soybean oil, ethyl oleate, GTCC, IPM, castor oil, masine-1, olive oil, IPP

Labrafil M1944, Labrasol, OP-10/ Transcutol P

Solid self-microemulsifying dispersible tablets

Increased bioavailability

[26]

Alginate and curcuin

Cremophor EL, Larafac PG, Capryol 90

Labrasol, Sodium CMC (absorbent), Aerosil 200

Curcumin loaded solid SMEDDS designed by freeze-drying technique

Enhance the release profile of drug

[28]

Dutasteride

Capryol 90

Cremophore EL/transcutol HP

Gelatin micropatrticles of a self-emulsified system

Enhanced oral bioavailability of dutasteride

[34]

Dutasteride

Capryol 90

Cremophore EL/ Transcutol HP

Soluplus-based supersaturable self-emulsifying drug delivery system

Improved oral absorption of dutasteride

[35]

Carbamazepine

Caprylic/ Capric triglycerides

Polysorbate 80/cremophore-RH 40

Solid self-microemulsifying drug delivery systems

Improved drug release and increase bioavailability

[45]

ELQ – 331 (antimalarial prodrug)

Tween-20, Span® 85, PEG 400 and sodium lauryl sulfate

Tween-20, Span® 85, PEG 400 and sodium lauryl sulfate

Preparation of spray dried dispersions and its comparison

Described the effect on the solubility and bioavailability of prodrug

[52]

Glyburide

Capryol 90, Lauroglycol 90, Labrafac Hydro WL 1219, polyglyceryl-3 dioleate

Labrasol, Tween 20/glycofurol, transcutol, PEG 400

fast-dissolving solid self-microemulsifying tablets

Improve dissolution and technological properties

[58]

Ritonavir

Imwitor 988

Cremophore EL and cremophore RH 40 (1:1)/capmul GMS K-50

Solid self-microemulsifying drug delivery system

Enhance dissolution and oral bioavailability of drug

[67]

Simvastatin

Capryol 90

Kolliphor EL/transcutol P

Self-emulsifying drug delivery system

Improved drug release

[68]

Carbamazepine

Mygliol 812

Cremophor EL/macrogol 400

Solid self-microemulsifying drug delivery systems (S-SMEDDS)

Increase in dissolution rate compared to pure Carbamazepine

[69]

Naproxen

Miglyol 812

Gelucire 44/14

Tablets and mini-tablets of spray dried SMEDDS

Lowered dissolution profile of naproxen from tablets and minitablets

[70]

Atrovastatin

Oleic acid and capryol 90

Caprol MPGO, Kolliphor RH40, Labrasol and Tween 80/PEG 400 and 1,2-propylene glycol

Liquid and solid Self-Emulsifying Drug Delivery Systems

better solubilization properties exhibited by solid formulation

[71]

Atorvastatin

Isopropyl myristate

lecithin/D-a-tocopheryl polyethylene glycol succinate/ethanol

Spray-dried self-microemulsifying drug delivery systems

Enhanced the cytotoxic activity on lung cancer cells

[72]

Paprika Oleoresin (carotenoid)

Limonene

Tween 80/ethanol

Solid self-microemulsifying system

Enhanced bioavailability and pigmentation

[73]

Naproxen

Miglyol 812

Gelucire 44/14/glycerin

Solid SMEDDS

Preserved the self- microemulsifying properties of liquid SMEDDS & exhibited dissolution profiles similar to liquid SMEDDS

[74]

Atorvastatin

Coconut oil and Isopropyl myristate

Tween 80/PEG 400 and glycerin

Solid self-micro emulsification system

Improve bioavailability

[75]

Mefanamic Acid

clove oil, olive oil and rice bran oil, Imwitor 742

Tween 60, cremophore El/transcutol HP

Self-emulsifying formulation

Enhance solubility

[76]

Atrovastatin calcium

Capmul® MCM

Tween® 20/tetraglycol

Solidified self-microemulsifying drug delivery system

Improve dissolution and bioavailability

[77]

Mebendazole

Labrafil 2125 CS

Tween 20/maisine 35-1

Self-microemulsifying drug delivery System

Improve dissolution and bioavailability

[78]

Huperzin

CremophorRH40

Propylene glycol

Self-microemusifying drug delivery system

Enhancing bioavailability and lymphatic uptake of the drug

[79]

Curcumin

Caprylic acid, cremophor RH 40, cremophor EL

Tween 80 and PEG 200

Vaginal self-emulsifying delivery system

Enhancement of drug penetration

[80]

Cathepsin K inhibitor (HL235)

Capmul MCM EP

Tween 20 (surfactant) and 20.0% carbitol (cosurfactant)

SEDDS were prepared by applying D-optimal mixture design

Improve drug solubility and drug loading. Increase bioavailability

[81]

Ferulic acid

Glyceryl triacetate, OP-10, Labrasol combination

PEG 400

Preparation of SMEDDS for

Enhancement of oral solubility of drug with improved hypnotic activity

[82]

Kaempferol and quercetin from plant Moringa oliefera

CrodamolTM P C (propylene glycol dicaprylocaprate)

Tween® 80 and polyethylene glycol 400

SMEDDS

Enhancement of solubility of the flavonoids

[83]

Nilotinib

Capryol 90

Transcutol HP and Tween 80

SMEDDS

Enhancement of solubility of the drug

[84]