Fig. 6

Hematoxylin and eosin (H&E) stained liver sections of DEN+CCl₄-induced mice (group V), a Centrilobular necrosis. b Fibrolamellar carcinoma liver where (A1) oncocytes, (A2) cord patterns, and nest formation which were separated by bands of (A3) fibrous stroma. c Peripheral/periportal necrosis shown by (B1) and (B2), and (C1) and (C2) (pyknotic condition in the nuclei of hepatic cells). d Trabecular or sinusoidal patterns which are made up of 2–8-cell-wide layers of tumor cells separated by vascular spaces or sinusoids which are lined by endothelium, e (D1) and (D2) Different changes in liver tissues like nodule formation and fibrosis or cirrhosis, respectively. f Large eosinophilic AHF. g Small basophilic AHF. h Vacuolated cell AHF. H&E stained liver sections are photographed at × 100 magnification