Table 5 Pharmacokinetic parameters of zotepine from zotepine coarse suspension (ZT-CS) and zotepine solid lipid nanoparticle (ZT-SLN) formulations after oral administration in rats (mean ± SD, n = 6)
Parameter | ZT-CS (F7) | ZT-SLN (F1) |
|---|---|---|
Cmax(μg/mL) | 1.8 ± 0.2 | 2.4 ± 0.6* |
Tmax(h) | 4 | 4 |
AUCtotal(μg/mL).h | 32.3 ± 1.1 | 43.3 ± 2.2* |
t1/2(h) | 16.0 ± 1.0 | 18.3 ± 2.3 |
MRT (h) | 19.7 ± 2.6 | 25.6 ± 1.5* |