Drug abs | Conc (mcg/ml) | Dilution factor | Actual drug conc in 1 ml (mcg/ml) | Drug in 5 ml (mcg/ml) | Total drug (mcg/ml) | Total cumulative drug release | Drug in mg | % cumulative drug release |
---|---|---|---|---|---|---|---|---|
AN | ||||||||
0.369 | 7.686440678 | 20 | 153.7288136 | 768.6440678 | 76,864.40678 | 76,864.40678 | 76.86440678 | 25.62146893 |
0.378 | 7.877118644 | 20 | 157.5423729 | 787.7118644 | 78,771.18644 | 79,539.83051 | 79.53983051 | 26.51327684 |
0.382 | 7.961864407 | 20 | 159.2372881 | 796.1864407 | 79,618.64407 | 80,406.35593 | 80.40635593 | 26.80211864 |
0.401 | 8.36440678 | 20 | 167.2881356 | 836.440678 | 83,644.0678 | 84,440.25424 | 84.44025424 | 28.14675141 |
0.409 | 8.533898305 | 20 | 170.6779661 | 853.3898305 | 85,338.98305 | 86,175.42373 | 86.17542373 | 28.72514124 |
0.444 | 9.275423729 | 20 | 185.5084746 | 927.5423729 | 92,754.23729 | 93,607.62712 | 93.60762712 | 31.20254237 |
CCs | ||||||||
0.529 | 11.07627119 | 25 | 276.9067797 | 1384.533898 | 13,8453.3898 | 138,453.3898 | 138.4533898 | 46.15112994 |
0.768 | 16.13983051 | 25 | 403.4957627 | 2017.478814 | 20,1747.8814 | 203,132.4153 | 203.1324153 | 67.71080508 |
0.836 | 17.58050847 | 25 | 439.5127119 | 2197.563559 | 21,9756.3559 | 221,773.8347 | 221.7738347 | 73.92461158 |
0.886 | 18.63983051 | 25 | 465.9957627 | 2329.978814 | 23,2997.8814 | 235,195.4449 | 235.1954449 | 78.39848164 |
0.942 | 19.82627119 | 25 | 495.6567797 | 2478.283898 | 24,7828.3898 | 250,158.3686 | 250.1583686 | 83.38612288 |
0.992 | 20.88559322 | 25 | 522.1398305 | 2610.699153 | 26,1069.9153 | 263,548.1992 | 263.5481992 | 87.84939972 |
Marketed formulation | ||||||||
0.465 | 9.720338983 | 25 | 243.0084746 | 1215.042373 | 12,1504.2373 | 122,719.2797 | 122.7192797 | 40.90642655 |
0.598 | 12.53813559 | 25 | 313.4533898 | 1567.266949 | 15,6726.6949 | 157,941.7373 | 157.9417373 | 52.64724576 |
0.645 | 13.53389831 | 25 | 338.3474576 | 1691.737288 | 16,9173.7288 | 170,740.9958 | 170.7409958 | 56.91366525 |
0.678 | 14.23305085 | 25 | 355.8262712 | 1779.131356 | 17,7913.1356 | 179,604.8729 | 179.6048729 | 59.86829096 |
0.683 | 14.33898305 | 25 | 358.4745763 | 1792.372881 | 17,9237.2881 | 181,016.4195 | 181.0164195 | 60.3388065 |
0.686 | 14.40254237 | 25 | 360.0635593 | 1800.317797 | 18,0031.7797 | 181,824.1525 | 181.8241525 | 60.60805085 |