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Table 6 Drug release study data

From: Preparation, characterization and evaluation of aspirin: benzoic acid cocrystals with enhanced pharmaceutical properties

Drug abs

Conc (mcg/ml)

Dilution factor

Actual drug conc in 1 ml (mcg/ml)

Drug in 5 ml (mcg/ml)

Total drug (mcg/ml)

Total cumulative drug release

Drug in mg

% cumulative drug release

AN

 0.369

7.686440678

20

153.7288136

768.6440678

76,864.40678

76,864.40678

76.86440678

25.62146893

 0.378

7.877118644

20

157.5423729

787.7118644

78,771.18644

79,539.83051

79.53983051

26.51327684

 0.382

7.961864407

20

159.2372881

796.1864407

79,618.64407

80,406.35593

80.40635593

26.80211864

 0.401

8.36440678

20

167.2881356

836.440678

83,644.0678

84,440.25424

84.44025424

28.14675141

 0.409

8.533898305

20

170.6779661

853.3898305

85,338.98305

86,175.42373

86.17542373

28.72514124

 0.444

9.275423729

20

185.5084746

927.5423729

92,754.23729

93,607.62712

93.60762712

31.20254237

CCs

 0.529

11.07627119

25

276.9067797

1384.533898

13,8453.3898

138,453.3898

138.4533898

46.15112994

 0.768

16.13983051

25

403.4957627

2017.478814

20,1747.8814

203,132.4153

203.1324153

67.71080508

 0.836

17.58050847

25

439.5127119

2197.563559

21,9756.3559

221,773.8347

221.7738347

73.92461158

 0.886

18.63983051

25

465.9957627

2329.978814

23,2997.8814

235,195.4449

235.1954449

78.39848164

 0.942

19.82627119

25

495.6567797

2478.283898

24,7828.3898

250,158.3686

250.1583686

83.38612288

 0.992

20.88559322

25

522.1398305

2610.699153

26,1069.9153

263,548.1992

263.5481992

87.84939972

Marketed formulation

 0.465

9.720338983

25

243.0084746

1215.042373

12,1504.2373

122,719.2797

122.7192797

40.90642655

 0.598

12.53813559

25

313.4533898

1567.266949

15,6726.6949

157,941.7373

157.9417373

52.64724576

 0.645

13.53389831

25

338.3474576

1691.737288

16,9173.7288

170,740.9958

170.7409958

56.91366525

 0.678

14.23305085

25

355.8262712

1779.131356

17,7913.1356

179,604.8729

179.6048729

59.86829096

 0.683

14.33898305

25

358.4745763

1792.372881

17,9237.2881

181,016.4195

181.0164195

60.3388065

 0.686

14.40254237

25

360.0635593

1800.317797

18,0031.7797

181,824.1525

181.8241525

60.60805085