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Table 2 Comparisons of clinical methods and POCT platforms for periodontitis diagnosis [7]

From: In situ gel drug delivery system for periodontitis: an insight review

Methods

Inspection

Palpation

Periodontal probing

Radiography

POCT platforms

Tools

Naked eye

Hands and tweezers

Various probes

2D/3D radiography equipment

Test kits, LOC/paper-based platform, wearable devices

Detection contents

Color, shape, and degree of gingival recession

The texture of the gingiva, tooth mobility

Degree of gingival bleeding, pocket probing depth, attachment level

Type and extent of alveolar bone loss

Biomarkers in saliva, GCF, and oral rinse

Parameters

Gingival index changes

Gingival texture and tooth mobility changes

Degree of bleeding and extent of soft-tissue destruction

Bone-tissue destruction

Levels of biomarkers

Convenience

Easy for dentists, difficult for non-dentists

Easy for dentists, difficult for non-dentists

Easy for the dentist and in-hospital use, difficult for non-dentist and on-site use

Easy in well-equipped settings, difficult in resource-limited settings

Mostly easy-to-use

Cost

Low

Low

Medium

Medium or high

Low

Prediction in progression

No

No

No

No

Yes