Table 3 Tableting properties of formulations I–IV

Mean weight (mg)

491 ± 9.68

497 ± 9.23

497 ± 8.65

491 ± 6.41

Drug content (%)

106.47 ± 13.34

102.48 ± 1.07

86.72 ± 9.22

97.35 ± 0.27

Thickness (mm)

3.83 ± 0.62

3.90 ± 0.08

3.90 ± 0.05

3.85 ± 0.03

Tensile strength (MPa)

1.38 ± 0.11

1.45 ± 0.08

1.62 ± 0.08

0.82 ± 0.04

Friability (%)

0.61 ± 0.29

0.61 ± 0.29

0.61 ± 0.28

1.43 ± 0.29

Disintegration time (min)

26.88 ± 4.17

11.48 ± 3.08

7.32 ± 2.66

1.33 ± 0.19