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Table 3 Tableting properties of formulations I–IV

From: Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression

Parameters I II III IV
Mean weight (mg) 491 ± 9.68 497 ± 9.23 497 ± 8.65 491 ± 6.41
Drug content (%) 106.47 ± 13.34 102.48 ± 1.07 86.72 ± 9.22 97.35 ± 0.27
Thickness (mm) 3.83 ± 0.62 3.90 ± 0.08 3.90 ± 0.05 3.85 ± 0.03
Tensile strength (MPa) 1.38 ± 0.11 1.45 ± 0.08 1.62 ± 0.08 0.82 ± 0.04
Friability (%) 0.61 ± 0.29 0.61 ± 0.29 0.61 ± 0.28 1.43 ± 0.29
Disintegration time (min) 26.88 ± 4.17 11.48 ± 3.08 7.32 ± 2.66 1.33 ± 0.19
  1. I MCC as DC excipient, II CPE as DC excipient, III PME as DC excipient, IV PSV as DC excipient