Skip to main content

Table 1 Anticancer activity of few previously reported quinazoline and pyrrole base derivative

From: Evaluation of antitumor potential of synthesized novel 2-substituted 4-anilinoquinazolines as quinazoline-pyrrole hybrids in MCF-7 human breast cancer cell line and A-549 human lung adenocarcinoma cell lines

Author

IUPAC name of the reported synthesized quinazoline/pyrrole derivatives

Cell line utilized

IC50 values (μM)

Standard IC50 values (μM)

Abuelizz et al. [24]

2-(Allylthio)-3-butyl-6-methylquinazolin-4(3H)-one

Cervical cancer (HeLa)

5.65

Gefitinib (4.3)

Human breast cancer (MDA-MB231)

3.77

Gefitinib (28.33)

Abuelizz et al. [24]

Butyl-6-methyl-2-(2-methylbenzylthio)-quinazolin-4(3H)-one

Cervical cancer (HeLa)

6.3

Gefitinib (4.3)

Human breast cancer (MDA-MB231)

4.44

Gefitinib (28.33)

Madhavi et al. [25]

(E)-1-(4-(Trifluoromethyl)phenyl)-3-(4-(quinazolin-4-ylamino)phenyl)prop-2-en-1-one

Human alveolar adenocarcinoma cell line (A459)

0.10

Combretastatin-A4 (0.11)

Human breast adenocarcinoma cell line (MCF-7)

0.17

Combretastatin-A4 (0.18)

Madhavi et al. [25]

(E)-1-(4-Methoxyphenyl)-3-(4-(quinazolin-4-ylamino)phenyl)prop-2-en-1-one

Human alveolar adenocarcinoma cell line (A459)

2.10

Combretastatin-A4 (0.11)

Human breast adenocarcinoma cell line (MCF-7)

0.16

Combretastatin-A4 (0.18)

Regin et al. [26]

1-(3-Aminophenyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)-methanone

Human cervical carcinoma (HeLa)

30

Vinblastin (10)

A-549 (human lung carcinoma)

10

Vinblastin (20.2)

Regin et al. [26]

1-(4-Methoxyphenyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)-methanone

Human cervical carcinoma (HeLa)

150

Vinblastin (10)

A-549 (human lung carcinoma)

80

Vinblastin (20.2)