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Table 11 Forced degradation study results for dolutegravir

From: A new validated stability-indicating RP-HPLC method for simultaneous quantification of dolutegravir and lamivudine in bulk and pharmaceutical dosage form

S. No Sample name % assay % degradation Purity angle Purity threshold Purity flag
1 Controlled sample 99.9 0.122 0.378 No
2 Acid degradation 95.1 4.8 0.397 0.475 No
3 Alkaline degradation 96.3 3.6 0.761 1.199 No
4 Peroxide degradation 91.4 8.5 1.618 2.154 No
5 Thermal degradation 97.6 2.3 0.397 0.498 No
6 UV degradation 98.1 1.8 0.454 0.492 No
7 Water degradation 98.6 1.3 0.292 0.458 No