Chemical profiling of a polyherbal formulation by tandem mass spectroscopic analysis with multiple ionization techniques

C. T., Sulaiman; P. R., Ramesh; K., Mahesh; K. M., Madhu; E. M., Anandan; M., Praveen; Balachandran, Indira

doi:10.1186/s43094-020-00062-w

Future Journal of Pharmaceutical Sciences

Table 3 Pharmacological properties of compounds identified from GTK

From: Chemical profiling of a polyherbal formulation by tandem mass spectroscopic analysis with multiple ionization techniques

Sl no.	Compounds identified from GTK	Pharmacological properties	Reference
1	Quinic acid	Anticancer, anti-inflammatory, neuroprotective, antioxidant	[19]
2	Syringic acid	Anticancer , anti-diabetic, anti-inflammatory, anti-microbial, hepatoprotective	[20, 21]
3	Protocatechuic acid	Anticancer, anti-diabetic, antiulcer, anti-inflammatory, analgesic, hepatoprotective	[22, 23]
4	2,5-Dihydroxybenzoic acid	Anti-inflammatory, antirheumatic, antioxidant	[24]
5	Gallic acid	Anticancer, antimicrobial, antioxidant, anti-inflammatory	[25]
6	Malic acid	Cardioprotective, antioxidant	[26]
7	Gallo catechin	Anticancer, anti-cholesterol, antioxidant	[27]
8	Anacardic acid (15:2)	Anticancer, anti-inflammatory, lipoxygenase (LOX-1), xanthine oxidase, tyrosinase	[28]
9	Anacardic acid (15:3)	Anticancer, anti-inflammatory, lipoxygenase (LOX-1), xanthine oxidase, tyrosinase	[28]
10	Anacardic acid (15:1)	Anticancer, anti-inflammatory, lipoxygenase (LOX-1), xanthine oxidase, tyrosinase	[28]
11	Caffeoylquinic acid	Anticancer, anti-inflammatory, lipoxygenase (LOX-1), xanthine oxidase, tyrosinase	[19]
12	Chebulic acid	Anti-diabetic, antioxidant, anti-angiogenic, anti-inflammatory	[29]
13	Quercetin hexoside	Aantioxidant, anti-inflammatory	[30]
14	Catechin	Anticancer, antioxidant, anti-inflammatory	[27, 31]
15	Cardanol	Anticancer, anti-inflammatory	[28]
16	Shikimic acid	Antimicrobial	[32]
17	Caffeic acid	Anticancer, antibacterial, antiviral activity, antioxidant, anti-inflammatory, anti-atherosclerotic, immunostimulatory, antidiabetic, cardioprotective, antiproliferative, hepatoprotective	[33]
18	6-Hydroxy flavone	Antioxidant, analgesic	[34]
19	2-Coumaric acid	Anticancer, antimicrobial, antioxidant, anti-inflammatory, antiproliferative	[35]
20	Ferulic acid	Anticancer, antioxidant, anti-inflammatory	[30]
21	Quercetin-3-rhamnoside	Anticancer, antioxidant, anti-inflammatory, antiviral, cardiovascular, antimicrobial	[30, 31]
22	2-O-caffeoylglucaric acid	Antioxidant, anti-inflammatory	[35]
23	Quercetin-3-glucuronide	Antioxidant, anti-inflammatory	[34]
24	2′,6-Dihydroxyflavanone	Antioxidant	[34]
25	Rutin	Anticancer, antioxidant, anti-inflammatory	[30, 31]
26	Quercetin-3-rhamnosyl glucoside	Antioxidant, anti-inflammatory	[31]
27	Kaempferol 7-O-glucoside	Anticancer, antioxidant, anti-inflammatory	[36]
28	Apigenin	Anticancer, antioxidant	[37]
29	7-Hydroxy-6-methoxy coumarin	Anticancer	[38]
30	4-Methylumbelliferone	Anticancer, anti-inflammatory, antibacterial, antifungal, antiviral	[39]
31	5-Methoxy-6,7-furanocoumarin	Anti-inflammatory, antibacterial, antifungal, antiviral	[39]
32	7-Hydroxycoumarin	Anticancer, anti-inflammatory	[39]
33	8-Acetyl-7-methoxycoumarin	Anticancer, anti-inflammatory	[39]
34	p-coumaric acid	Anticancer, antimicrobial, antioxidant, anti-inflammatory	[35]
35	Azelaic acid	Anticancer, antityrosinase, antibacterial	[40, 41]
36	Betulinic acid	Anticancer, antioxidant	[42]
37	5,7,3′-trihydroxy-4′-methoxyflavone	Anticancer	[43]
38	Apigenin 7-O-glucoside	Anticancer, antioxidant	[37]

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