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Future Journal of Pharmaceutical Sciences

Table 1 Retardation factors of p-, m-, and o-nitrophenol, and R(−)-, S(+)-ibuprofen developed on SC-2P/Cu2+ TLC plates using different mobile phase systems (MPs)

From: A new bonded silica based on an amino acid derivative as a TLC stationary phase to solve nitrophenol structural isomerism and ibuprofen stereoisomerism

Nitrophenols

MP-1

MP-2

MP-3

MP-4

MP-5

p-isomerRf

0.09

0.12

0.56

0.28

0.67

m-isomerRf

0.19

0.22

0.86

0.45

0.79

o-isomerRf

0.85

0.91

0.89

0.83

0.87

(±)-Ibuprofen

MP-6

MP-7

MP-8

MP-9

 

R(−)-ibuprofenRf

0.79

0.59

0.43

0.39

 

S(+)-ibuprofenRf

0.82

0.67

0.63

0.54

 
  1. MP-1 n-hexane:DCE (50:50), MP-2 n-hexane:DCE (75:25), MP-3 n-hexane:DCE:2-propanol (75:20:5), MP-4 n-hexane:DCE:n-propanol (75:20:5), MP-5 n-hexane:DCE:n-propanol (75:15:10), MP-6 DCE:Acetonitrile (70:30), MP-7 DCE:Acetonitrile (80:20), MP-8 DCE:Acetonitrile (90:10), MP-9 DCE:Acetonitrile (95:5)
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