Table 6 Pharmacokinetic parameters of MLC in rabbit plasma after oral administration of MELFLAM tab (15 mg) tablets and Bulk drug (n = 6)

Cmax^a, μg mL⁻¹

0.6577 ± 0.01

0.7792 ± 0.01

118.50% (115.21, 121.78)^b

0.0002

Tmax, h

6.1 ± 0.36 (5.8–6.5)

4.0 ± 0.46 (3.5–4.4)

–

0.9853

T_1/2, h

21.5261 ± 0.57

20.3629 ± 0.20

–

0.7709

AUC0-t^a , μg h mL⁻¹

17.3070 ± 0.29

19.7973 ± 1.06

114.57 (106.66, 122.47)^b

0.0146

AUC0-∞^a , μg h mL⁻¹

25.2047 ± 0.67

25.1649 ± 0.89

100.09 (91.76, 108.41)^b

0.9493

MRT, h

31.2453 ± 0.69

29.3837 ± 0.55

–

0.2436

Ke

0.0320 ± 0.01

0.0340 ± 0.01

–

0.4826