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Table 6 Pharmacokinetic parameters of MLC in rabbit plasma after oral administration of MELFLAM tab (15 mg) tablets and Bulk drug (n = 6)

From: Meloxicam quantification in rabbit plasma by RP-HPLC: optimization and application to pharmacokinetic study

Pharmacokinetic parameter Reference (mean ± SD) Test (mean ± SD) Geometric mean ratio of T/R (90% CI)a P value
Cmaxa, μg mL−1 0.6577 ± 0.01 0.7792 ± 0.01 118.50% (115.21, 121.78)b 0.0002
Tmax, h 6.1 ± 0.36 (5.8–6.5) 4.0 ± 0.46 (3.5–4.4) 0.9853
T1/2, h 21.5261 ± 0.57 20.3629 ± 0.20 0.7709
AUC0-ta , μg h mL−1 17.3070 ± 0.29 19.7973 ± 1.06 114.57 (106.66, 122.47)b 0.0146
AUC0-∞a , μg h mL−1 25.2047 ± 0.67 25.1649 ± 0.89 100.09 (91.76, 108.41)b 0.9493
MRT, h 31.2453 ± 0.69 29.3837 ± 0.55 0.2436
Ke 0.0320 ± 0.01 0.0340 ± 0.01 0.4826
  1. a Bioequivalence criteria are defined as 90% CI of the geometric mean ratios of the test formulation/reference formulation lies between 80.00% and 125.00% for AUC0-t, AUC0-∞, and Cmax bStatistical calculations for AUC and Cmax were based on log-transformed data; c values in the bracket indicate with range (lowest Tmax – highest Tmax)