From: Improved comprehensive analytical method for assessment of satranidazole in drug and product
Solvent | Method | Regression analysis | Validation parameters | ||||||
---|---|---|---|---|---|---|---|---|---|
Slope (S.Ea) | 95% CLb of slope | Intercept (S.Ec) | 95% CL of icptd | R2 | 95% CL of te | LODf (μg ml−1) | LOQg (μg ml−1) | ||
Methanol | A | 0.048 (0) | – | 0.027 (0.0010) | 3.94E−05 | 0.998 | 0.3804 | 0.0859 | 0.2604 |
B | 0.027 (0.0005) | 1.56E−05 | 0.044 (0.0049) | 0.000126 | 0.999 | 0.1449 | 0.4925 | 1.4814 | |
C |  | 7.83E−05 | 0.308 (0.1493) | 0.004484 | 0.999 | 0.0630 | 1.3961 | 4.2307 | |
Ethanol | A | Â | 0.077072 | 0.118 (0.0078) | 0.000387 | 0.999 | 0.5971 | 1.9328 | 5.9725 |
B | 0.015 (0) | 0.337 (0.0030) | 0.107 (0.0007) | 6.00E−05 | 0.999 | 0.8314 | 0.4210 | 1.2758 | |
C | 0.171 (0.0064) | 0.021 (0.0031) | 1.259 (0.1947) | 0.00616 | 0.999 | 0.5142 | 3.7901 | 11.4084 | |
DMF | A | 0.056 (0.0104) | 0.00032 | 0.095 (0.0227) | 0.00070 | 0.999 | 0.4931 | 1.0690 | 3.2178 |
B | 0.044 (0) | – | 0.092 (0.0024) | 5.91E−05 | 0.999 | 0.0873 | 0.18 | 0.5418 | |
C | 0.647 (0.0010) | 0.03354 | 0.855 (0.0700) | 0.002667 | 0.999 | 0.1877 | 0.3570 | 1.0746 | |
Benzene | A | 0.037 (4.6E-05) | 0.00101 | 0.040 (0.0013) | 0.029218 | 0.999 | 0.1116 | 0.1203 | 0.3623 |
B | 0.026 (2.5E−05) | 0.00096 | 0.044 (0.0006) | 0.025024 | 0.999 | 0.3036 | 0.0805 | 0.2495 | |
C | 0.192 (3.6E−05) | 0.00122 | 0.347 (0.0019) | 0.06532 | 0.999 | 0.6097 | 0.0332 | 0.1002 | |
Acetonitrile | A | 0.105 (0.0047) | 0.000128 | 0.013 (0.0225) | 0.00058 | 0.999 | 0.1675 | 0.7071 | 2.1285 |
B | 0.064 (0.0018) | 6.46E−05 | 0.007 (0.0117) | 0.00036 | 0.999 | 0.7152 | 0.6037 | 1.8174 | |
C | 0.871 (0.0441) | 0.001319 | 0.087 (0.2136) | 0.006256 | 0.999 | 0.1083 | 0.8092 | 2.4359 | |
Meth chloride | A | 0.043 (0) | – | − 0.006 (0.0060) | 0.00018 | 0.999 | 0.0171 | 0.4662 | 1.4033 |
B | 0.026 (0.0004) | 1.70E-05 | − 0.039 (0.0061) | 0.000231 | 0.999 | 0.1455 | 0.7742 | 2.3304 | |
C | 0.410 (0.0303) | 0.000537 | − 0.513 (0.1474) | 0.005395 | 0.999 | 0.7257 | 1.1863 | 3.5710 | |
DDW | A | 0.033 (0.0011) | 4.92E-05 | (7E−06) (2.2E−06) | 0.00076 | 0.999 | 0.0764 | 0.0002 | 0.0006 |
B | 0.021 (0) | – | 0.004 (5.5E−05) | 0.00012 | 0.999 | 0.0245 | 0.0086 | 0.0267 | |
C | 0.281 (0.0091) | 0.00091 | − 0.031 (0.00124) | 1.92E−05 | 0.999 | 0.0875 | 0.0145 | 0.0451 |