Table 4 Summary of accuracy results by standard addition technique for pharmaceutical product form of satranidazole (STZ )(n = 10)
From: Improved comprehensive analytical method for assessment of satranidazole in drug and product
Solvent used | Drug taken (μg ml−1) | Method | % Recovery (±RSD) | |||
|---|---|---|---|---|---|---|
Pure drug added (recovery level) | ||||||
0% | 80% | 100% | 120% | |||
DD water | 13 | A | 100.30 ± 0.53 | 100.91 ± 0.04 | 101.23 ± 1.00 | 99.97 ± 0.49 |
B | 99.85 ± 0.61 | 99.70 ± 1.49 | 98.95 ± 1.36 | 100.56 ± 0.59 | ||
C | 100.46 ± 0.53 | 100.43 ± 1.24 | 100.23 ± 0.77 | 100.49 ± 0.56 | ||
Methanol | 11 | A | 100.27 ± 0.98 | 100.15 ± 0.15 | 101.82 ± 0.18 | 100.16 ± 0.74 |
B | 101.36 ± 0.18 | 99.39 ± 0.05 | 101.86 ± 0.81 | 101.74 ± 0.21 | ||
C | 101.91 ± 0.81 | 99.84 ± 0.05 | 101.27 ± 0.90 | 100.41 ± 0.83 | ||
Ethanol | 18 | A | 99.61 ± 0.45 | 99.32 ± 0.92 | 100.00 ± 0.72 | 101.24 ± 0.81 |
B | 99.79 ± 0.56 | 101.23 ± 1.24 | 98.99 ± 0.12 | 100.43 ± 0.68 | ||
C | 100.44 ± 0.16 | 100.18 ± 0.58 | 99.86 ± 0.04 | 98.51 ± 0.73 | ||
DMF | 6 | A | 99.86 ± 0.39 | 100.28 ± 0.37 | 100.25 ± 0.33 | 99.09 ± 0.45 |
B | 99.58 ± 0.50 | 100.37 ± 0.40 | 98.92 ± 0.42 | 100.45 ± 0.83 | ||
C | 100.25 ± 0.17 | 100.55 ± 0.65 | 98.90 ± 0.83 | 100.00 ± 0.78 | ||
Methonol | 11 | A | 99.97 ± 0.32 | 99.26 ± 1.39 | 100.94 ± 1.60 | 101.30 ± 0.40 |
B | 99.68 ± 0.39 | 101.90 ± 1.00 | 101.19 ± 0.80 | 100.83 ± 1.27 | ||
C | 99.58 ± 0.98 | 100.00 ± 0.00 | 100.00 ± 1.42 | 100.63 ± 0.89 | ||
Benzene | 13 | A | 100.10 ± 0.81 | 99.97 ± 0.03 | 101.13 ± 0.16 | 99.56 ± 0.07 |
B | 100.42 ± 0.82 | 101.50 ± 0.70 | 99.58 ± 1.10 | 99.1 ± 0.66 | ||
C | 99.89 ± 0.06 | 101.78 ± 0.80 | 100.50 ± 0.20 | 99.68 ± 0.04 | ||
Acetonitrile | 4 | A | 99.98 ± 0.59 | 100.13 ± 0.24 | 100.89 ± 0.41 | 101.13 ± 0.01 |
B | 100.05 ± 0.99 | 100.44 ± 0.16 | 100.00 ± 0.03 | 100.4 ± 0.09 | ||
C | 99.82 ± 0.06 | 100.06 ± 1.60 | 100.08 ± 0.29 | 100.9 ± 0.02 | ||