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Table 5 Determination of satranidazole (STZ) from pharmaceutical product by spectrophotometric method

From: Improved comprehensive analytical method for assessment of satranidazole in drug and product

Solvent

Label

claimed

(mg)

Method

Amount of STZ found (mg/tab)

% Recovery ±S.D.

%RSD

Accuracy a (%)

95% C.L

of tb

%RSDc

Double distilled water

300

A

298.488 ± 0.117

99.496 ± 0.039

0.039

− 0.504

2.19

0.023

B

299.349 ± 0.123

99.783 ± 0.041

0.041

− 0.217

1.53

0.024

C

298.92 ± 0.294

99.64 ± 0.098

0.098

− 0.36

1.95

0.581

Methanol

300

A

302.454 ± 0.141

100.81 ± 0.047

0.046

0.818

1.36

0.028

B

301.848 ± 2.91

100.61 ± 0.970

0.964

0.616

1.91

0.577

C

302.115 ± 2.601

100.70 ± 0.867

0.860

0.705

2.11

0.516

Ethanol

300

A

302.058 ± 2.481

100.68 ± 0.806

0.821

0.686

2.14

0.492

B

301.917 ± 2.16

100.63 ± 0.720

0.715

0.639

2.16

0.428

C

300.804 ± 2.385

100.26 ± 0.795

0.792

0.268

1.01

0.473

DMF

300

A

301.701 ± 2.889

100.56 ± 0.963

0.957

0.567

1.77

0.573

B

301.803 ± 1.911

100. 60 ± 0.637

0.633

0.601

2.06

0.379

C

301.887 ± 0.225

100.62 ± 0.075

0.074

0.629

2.15

0.045

Benzene

300

A

301.971 ± 1.083

100.65 ± 0.361

0.358

0.657

1.39

0.215

B

300.861 ± 2.754

100.28 ± 0.918

0.915

0.287

0.94

0.546

C

300.204 ± 0.084

100.06 ± 0.028

0.027

0.068

1.77

0.017

Acetonitrile

300

A

297.540 ± 1.419

99. 180 ± 0.473

0.476

− 0.820

1.26

0.281

B

297.507 ± 2.124

99. 169 ± 0.708

0.713

− 0.831

1.33

0.421

C

297.174 ± 2.028

99. 058 ± 0.676

0.682

− 0.942

1.82

0.402

Dichloro methane

300

A

299.034 ± 2.043

99. 678 ± 0.681

0.683

− 0.322

1.41

0.405

B

297.504 ± 2.844

99. 168 ± 0.948

0.955

− 0.832

2.20

0.563

C

299.769 ± 1.08

99.923 ± 0. 360

0.360

− 0.077

0.64

0.214

  1. a% relative error \( =100\ast \frac{{\mathrm{Conc}}_{\mathrm{predicted}}-{\mathrm{Conc}}_{\mathrm{normal}}}{{\mathrm{Conc}}_{\mathrm{normal}}} \)
  2. btheoretical values (95% confidence limit), t = 2.225
  3. cIntra-day RSD value