From: Improved comprehensive analytical method for assessment of satranidazole in drug and product
Solvent | Label claimed (mg) | Method | Amount of STZ found (mg/tab) | % Recovery ±S.D. | %RSD | Accuracy a (%) | 95% C.L of tb | %RSDc |
---|---|---|---|---|---|---|---|---|
Double distilled water | 300 | A | 298.488 ± 0.117 | 99.496 ± 0.039 | 0.039 | − 0.504 | 2.19 | 0.023 |
B | 299.349 ± 0.123 | 99.783 ± 0.041 | 0.041 | − 0.217 | 1.53 | 0.024 | ||
C | 298.92 ± 0.294 | 99.64 ± 0.098 | 0.098 | − 0.36 | 1.95 | 0.581 | ||
Methanol | 300 | A | 302.454 ± 0.141 | 100.81 ± 0.047 | 0.046 | 0.818 | 1.36 | 0.028 |
B | 301.848 ± 2.91 | 100.61 ± 0.970 | 0.964 | 0.616 | 1.91 | 0.577 | ||
C | 302.115 ± 2.601 | 100.70 ± 0.867 | 0.860 | 0.705 | 2.11 | 0.516 | ||
Ethanol | 300 | A | 302.058 ± 2.481 | 100.68 ± 0.806 | 0.821 | 0.686 | 2.14 | 0.492 |
B | 301.917 ± 2.16 | 100.63 ± 0.720 | 0.715 | 0.639 | 2.16 | 0.428 | ||
C | 300.804 ± 2.385 | 100.26 ± 0.795 | 0.792 | 0.268 | 1.01 | 0.473 | ||
DMF | 300 | A | 301.701 ± 2.889 | 100.56 ± 0.963 | 0.957 | 0.567 | 1.77 | 0.573 |
B | 301.803 ± 1.911 | 100. 60 ± 0.637 | 0.633 | 0.601 | 2.06 | 0.379 | ||
C | 301.887 ± 0.225 | 100.62 ± 0.075 | 0.074 | 0.629 | 2.15 | 0.045 | ||
Benzene | 300 | A | 301.971 ± 1.083 | 100.65 ± 0.361 | 0.358 | 0.657 | 1.39 | 0.215 |
B | 300.861 ± 2.754 | 100.28 ± 0.918 | 0.915 | 0.287 | 0.94 | 0.546 | ||
C | 300.204 ± 0.084 | 100.06 ± 0.028 | 0.027 | 0.068 | 1.77 | 0.017 | ||
Acetonitrile | 300 | A | 297.540 ± 1.419 | 99. 180 ± 0.473 | 0.476 | − 0.820 | 1.26 | 0.281 |
B | 297.507 ± 2.124 | 99. 169 ± 0.708 | 0.713 | − 0.831 | 1.33 | 0.421 | ||
C | 297.174 ± 2.028 | 99. 058 ± 0.676 | 0.682 | − 0.942 | 1.82 | 0.402 | ||
Dichloro methane | 300 | A | 299.034 ± 2.043 | 99. 678 ± 0.681 | 0.683 | − 0.322 | 1.41 | 0.405 |
B | 297.504 ± 2.844 | 99. 168 ± 0.948 | 0.955 | − 0.832 | 2.20 | 0.563 | ||
C | 299.769 ± 1.08 | 99.923 ± 0. 360 | 0.360 | − 0.077 | 0.64 | 0.214 |