Fig. 6

Microscopic observation of the kidney in the experimental tissue section. a Normal control-light micrographs of rat kidney tissue in normal kidney depicted normal renal corpuscle with glomerulus and architecture. b Diabetic control-nonappearance of renal corpuscle, glomerulus, and abnormal architecture. c Diabetic+glibenclamide-various regions of the kidney tubules appeared to be normal without any changes in the mesangial matrix. d Diabetic+EEPM (50 mg/kg) section of kidney showing few changes compares with normal control and less appearance of cells. e Diabetic+EEPM (100 mg/kg) and (F) diabetic+EEPM (200 mg/kg) various regions of kidneys of treated animals revealed absence of matrix expansion and glomerular basement membrane thickening; suggesting became normal histoarchitecture of renal