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Table 2 Results showing the time course of onset of signs of toxicity in rats treated with 5000 mg/kg/b.w EEPM fruits

From: Antidiabetic effects of P. macrocarpa ethanolic fruit extract in streptozotocin-induced diabetic rats

Observations

Control group

Test group

Mortality

6 h

7 days

6 h

7 days

Control group

Test group

Physical activity

N

N

N

N

Nil

Nil

CNS activity

N

N

N

N

ANS profile

N

N

N

N

Skin and fur

N

N

N

N

Eyes

N

N

N

N

Mucous membrane

N

N

N

N

Salivation

N

N

N

N

Lethargy

N

N

N

N

Sleep

N

N

N

 

Diarrhea

N

N

N

N

Coma

N.O*

N.O*

N.O*

N.O*

Tremors

N.O*

N.O*

N.O*

N.O*

  1. N normal, N.O* not observed