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Table 2 Forced Degradation of ERTU and MET

From: Development and validation of stability-indicating RP-HPLC method for the simultaneous determination of ertugliflozin pidolate and metformin hydrochloride in bulk and tablets

Stressor

ERTU

MET

Purity angle

Purity threshold

% Assay

% Degraded

Purity angle

Purity threshold

% Assay

% Degraded

Acid

1.493

1.966

92.45

7.55

1.448

1.801

92.29

7.71

Alkali

1.766

2.146

94.56

5.44

1.402

1.752

93.07

6.93

Oxidative

1.693

2.130

95.42

4.58

1.348

2.270

94.47

5.53

Thermal

1.936

2.341

96.86

3.14

2.753

2.927

97.07

2.93

Photolytic

1.659

2.009

98.30

1.70

2.489

2.786

98.21

1.79

Neutral

1.780

2.134

98.98

1.02

2.358

2.915

99.10

0.90