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Table 2 Forced Degradation of ERTU and MET

From: Development and validation of stability-indicating RP-HPLC method for the simultaneous determination of ertugliflozin pidolate and metformin hydrochloride in bulk and tablets

Stressor ERTU MET
Purity angle Purity threshold % Assay % Degraded Purity angle Purity threshold % Assay % Degraded
Acid 1.493 1.966 92.45 7.55 1.448 1.801 92.29 7.71
Alkali 1.766 2.146 94.56 5.44 1.402 1.752 93.07 6.93
Oxidative 1.693 2.130 95.42 4.58 1.348 2.270 94.47 5.53
Thermal 1.936 2.341 96.86 3.14 2.753 2.927 97.07 2.93
Photolytic 1.659 2.009 98.30 1.70 2.489 2.786 98.21 1.79
Neutral 1.780 2.134 98.98 1.02 2.358 2.915 99.10 0.90