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Table 5 Results of tablets (products X and Y) analysis by the PCA, DDQ and official methods and their statistical comparison

From: Application of two charge transfer complex formation reactions for selective determination of metformin hydrochloride in pharmaceuticals and urine

Product analyzed

Label claim, mg MFH/tablet

Founda (percent of label claim ±SD)

Official method

PCA method

DDQ method

X

500

99.47 ± 1.01

100.21 ± 1.45

99.97 ± 1.79

t = 0.95

t = 0.55

F = 2.06

F = 3.14

Y

500

99.70 ± 1.56

99.51 ± 0.98

100.30 ± 1.17

t = 0.23

t = 0.69

F = 2.53

F = 1.78

  1. aAverage of 5 determinations
  2. ttab and Ftab values for four degrees freedom are 2.77 and 6.39, respectively