Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide

Future Journal of Pharmaceutical Sciences

Table 1 List of drug–drug cocrystals patented and clinical development phase

Sl. No	API–API	Company/country	Year	Ref	Current status
1	Pyrithyldione–propyphenazone	F. Hoffmann-La Roche AG/Switzerland	1937	[32]	Patented
2	Valproate sodium–valproic acid	Abbott Laboratories/Canada	2000	[33, 34]	Patented
3	Tramadol–naproxen	Laboratorios Del. Dr. Esteve, S.A./Spain	2010	[61]	Patented
4	Tramadol–paracetamol	Laboratorios Del. Dr. Esteve, S.A./Spain	2010	[36]	Patented
5	Venlafaxine–celecoxib	Laboratorios Del. Dr. Esteve, S.A./Spain	2011	[37]	Patented
6	Ticagrelor–aspirin	Astrazeneca UK Ltd/UK	2012	[27]	Patented
7	Metformin–oleoylethanolamide	Nutracryst Therapeutic Pvt Ltd/India	2012	[38]	Patented
8	Quercetin–metformin	Nutracryst Therapeutic Pvt Ltd/India	2012	[39]	Patented
9	Duloxetine–naproxen	Laboratorios Del. Dr. Esteve, S.A./Spain	2013	[40]	Patented
10	Telmisartan–beta blockers	Laboratorios Del. Dr. Esteve, S.A./Spain	2013	[41]	Patented
11	Cyprodinil–dithianon	BASF company Ltd/China	2013	[42]	Patented
12	Acetyl salicylic acid–theanine	Theaprin Pharmaceuticals Inc/USA	2015	[62]	Patented
13	Sacubitril–valsartan	Novartis/UK	2015	[24]	Marketed
14	Tramadol–celecoxib	Laboratorios Del. Dr. Esteve, S.A/Spain	2016	[35]	Clinical development phase