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Table 3 Predicted drug-likeness based on the Lipinski, Ghose, Veber, Egan, and Muegge rules and synthetic accessibility of the selected compounds

From: In silico evaluation of some 4-(quinolin-2-yl)pyrimidin-2-amine derivatives as potent V600E-BRAF inhibitors with pharmacokinetics ADMET and drug-likeness predictions

SN Lipinski Ghose Veber Egan Muegge Synthetic accessibility
5 0 1 0 1 0 2.91
9 0 1 0 1 0 3.13
10 0 1 0 1 0 3.06
11 0 0 0 0 0 3.2
Vem. 0 2 0 1 0 3.38