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Table 3 Predicted drug-likeness based on the Lipinski, Ghose, Veber, Egan, and Muegge rules and synthetic accessibility of the selected compounds

From: In silico evaluation of some 4-(quinolin-2-yl)pyrimidin-2-amine derivatives as potent V600E-BRAF inhibitors with pharmacokinetics ADMET and drug-likeness predictions

SN

Lipinski

Ghose

Veber

Egan

Muegge

Synthetic accessibility

5

0

1

0

1

0

2.91

9

0

1

0

1

0

3.13

10

0

1

0

1

0

3.06

11

0

0

0

0

0

3.2

Vem.

0

2

0

1

0

3.38