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Table 2 Central composite design by statistical software minitab 17.3.0

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Run order Citric acid (mg) Effersoda (mg)
Coded value Actual value Coded value Actual value
1 0.0000 640.00 − 1.41421 187.45
2 + 1.41421 1092.55 0.0000 640.00
3 0.0000 640.00 0.0000 640.00
4 0.0000 640.00 0.0000 640.00
5 0.0000 640.00 + 1.41421 1092.55
6 0.0000 640.00 0.0000 640.00
7 − 1.41421 187.45 0.0000 640.00
8 0.0000 640.00 0.0000 640.00
9 0.0000 640.00 0.0000 640.00
10 + 1.0000 960.00 + 1.0000 960.00
11 − 1.0000 320.00 − 1.0000 320.00
12 − 1.0000 320.00 + 1.0000 960.00
13 0.0000 640.00 0.0000 640.00
14 + 1.0000 960.00 − 1.0000 320.00