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Table 2 Central composite design by statistical software minitab 17.3.0

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Run order

Citric acid (mg)

Effersoda (mg)

Coded value

Actual value

Coded value

Actual value

1

0.0000

640.00

āˆ’ 1.41421

187.45

2

+ 1.41421

1092.55

0.0000

640.00

3

0.0000

640.00

0.0000

640.00

4

0.0000

640.00

0.0000

640.00

5

0.0000

640.00

+ 1.41421

1092.55

6

0.0000

640.00

0.0000

640.00

7

āˆ’ 1.41421

187.45

0.0000

640.00

8

0.0000

640.00

0.0000

640.00

9

0.0000

640.00

0.0000

640.00

10

+ 1.0000

960.00

+ 1.0000

960.00

11

āˆ’ 1.0000

320.00

āˆ’ 1.0000

320.00

12

āˆ’ 1.0000

320.00

+ 1.0000

960.00

13

0.0000

640.00

0.0000

640.00

14

+ 1.0000

960.00

āˆ’ 1.0000

320.00