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Table 3 Composition of levetiracetam effervescent tablets 500 mg

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

  C1 C2 C3 C4 C5 C6 C7 C8 C9 C10 C11 C12 C13 C14
Intragranular (for compaction)               
 Levetiracetam 500 500 500 500 500 500 500 500 500 500 500 500 500 500
 Anhydrous lactose (lactose 21AN) 700 700 700 700 700 700 700 700 700 700 700 700 700 700
 Colloidal silicon dioxide 16 16 16 16 16 16 16 16 16 16 16 16 16 16
 Sodium benzoate 16 16 16 16 16 16 16 16 16 16 16 16 16 16
 Sodium acetate 16 16 16 16 16 16 16 16 16 16 16 16 16 16
Extra granular               
 Mannitol (Pearlitol 200 SD) 286 286 286 286 286 286 286 286 286 286 286 286 286 286
 Sorbitol (Neosorb® XTAB 300S ) 220 220 220 220 220 220 220 220 220 220 220 220 220 220
 Citric acid 640 1092.55 640 640 640 640 187.45 640 640 960 320 320 640 960
 Effersoda 187.45 640 640 640 1092.55 640 640 640 640 960 320 960 640 320
 Aspartame 60 60 60 60 60 60 60 60 60 60 60 60 60 60
 Orange flavor 26 26 26 26 26 26 26 26 26 26 26 26 26 26
 Colloidal silicon dioxide 16 16 16 16 16 16 16 16 16 16 16 16 16 16
 Sodium benzoate 32 32 32 32 32 32 32 32 32 32 32 32 32 32
 Sodium acetate 32 32 32 32 32 32 32 32 32 32 32 32 32 32
 Total (mg) 2747.45 3652.55 3200 3200 3652.55 3200 2747.45 3200 3200 3840 2560 3200 3200 3200