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Table 3 Composition of levetiracetam effervescent tablets 500 mg

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

 

C1

C2

C3

C4

C5

C6

C7

C8

C9

C10

C11

C12

C13

C14

Intragranular (for compaction)

              

 Levetiracetam

500

500

500

500

500

500

500

500

500

500

500

500

500

500

 Anhydrous lactose (lactose 21AN)

700

700

700

700

700

700

700

700

700

700

700

700

700

700

 Colloidal silicon dioxide

16

16

16

16

16

16

16

16

16

16

16

16

16

16

 Sodium benzoate

16

16

16

16

16

16

16

16

16

16

16

16

16

16

 Sodium acetate

16

16

16

16

16

16

16

16

16

16

16

16

16

16

Extra granular

              

 Mannitol (Pearlitol 200 SD)

286

286

286

286

286

286

286

286

286

286

286

286

286

286

 Sorbitol (Neosorb® XTAB 300S )

220

220

220

220

220

220

220

220

220

220

220

220

220

220

 Citric acid

640

1092.55

640

640

640

640

187.45

640

640

960

320

320

640

960

 Effersoda

187.45

640

640

640

1092.55

640

640

640

640

960

320

960

640

320

 Aspartame

60

60

60

60

60

60

60

60

60

60

60

60

60

60

 Orange flavor

26

26

26

26

26

26

26

26

26

26

26

26

26

26

 Colloidal silicon dioxide

16

16

16

16

16

16

16

16

16

16

16

16

16

16

 Sodium benzoate

32

32

32

32

32

32

32

32

32

32

32

32

32

32

 Sodium acetate

32

32

32

32

32

32

32

32

32

32

32

32

32

32

 Total (mg)

2747.45

3652.55

3200

3200

3652.55

3200

2747.45

3200

3200

3840

2560

3200

3200

3200