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Table 4 Evaluation of powder blend properties (formulation C1-C14)

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Evaluation of powder blend properties
Batch code Bulk density (gm/ml) Tap density (gm/ml) Carr’s index (CI) Hausner’s ratio Angle of repose (°) LOD of blend (%)
C1 0.61 0.75 18.52 1.23 35.24 2.19 ± 0.44
C2 0.53 0.69 23.47 1.31 41.25 2.22 ± 0.39
C3 0.60 0.75 19.41 1.24 37.21 2.13 ± 0.54
C4 0.58 0.73 21.05 1.27 39.41 2.25 ± 0.37
C5 0.52 0.68 24.05 1.32 41.32 2.33 ± 0.21
C6 0.61 0.76 19.59 1.24 38.22 2.18 ± 0.32
C7 0.60 0.76 20.47 1.26 42.22 2.36 ± 0.51
C8 0.59 0.74 20.08 1.25 36.21 2.44 ± 0.36
C9 0.58 0.76 23.82 1.31 39.39 2.06 ± 0.48
C10 0.51 0.69 26.76 1.37 45.04 2.33 ± 0.11
C11 0.63 0.81 22.84 1.30 38.83 2.28 ± 0.25
C12 0.59 0.73 19.35 1.24 40.22 2.05 ± 0.35
C13 0.60 0.75 20.29 1.25 37.54 2.31 ± 0.14
C14 0.58 0.73 21.05 1.27 38.61 2.13 ± 0.03