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Future Journal of Pharmaceutical Sciences

Table 4 Evaluation of powder blend properties (formulation C1-C14)

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Evaluation of powder blend properties

Batch code

Bulk density (gm/ml)

Tap density (gm/ml)

Carr’s index (CI)

Hausner’s ratio

Angle of repose (°)

LOD of blend (%)

C1

0.61

0.75

18.52

1.23

35.24

2.19 ± 0.44

C2

0.53

0.69

23.47

1.31

41.25

2.22 ± 0.39

C3

0.60

0.75

19.41

1.24

37.21

2.13 ± 0.54

C4

0.58

0.73

21.05

1.27

39.41

2.25 ± 0.37

C5

0.52

0.68

24.05

1.32

41.32

2.33 ± 0.21

C6

0.61

0.76

19.59

1.24

38.22

2.18 ± 0.32

C7

0.60

0.76

20.47

1.26

42.22

2.36 ± 0.51

C8

0.59

0.74

20.08

1.25

36.21

2.44 ± 0.36

C9

0.58

0.76

23.82

1.31

39.39

2.06 ± 0.48

C10

0.51

0.69

26.76

1.37

45.04

2.33 ± 0.11

C11

0.63

0.81

22.84

1.30

38.83

2.28 ± 0.25

C12

0.59

0.73

19.35

1.24

40.22

2.05 ± 0.35

C13

0.60

0.75

20.29

1.25

37.54

2.31 ± 0.14

C14

0.58

0.73

21.05

1.27

38.61

2.13 ± 0.03

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