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Table 5 Physicochemical properties of tablets (formulation C1-C14)

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Physicochemical properties of tablets
Batch code Weight variation (mg) Hardness (N) Friability (%) Effervescent time (s) Amount of carbon dioxide (g) Drug content analysis (%) % drug release at 5 min
C1 2747.45 ± 2.9 125 ± 2.25 0.92 68 0.11 ± 0.08 100.8 90.2 ± 0.12
C2 3652.55 ± 2.5 125 ± 3.41 0.88 80 0.17 ± 0.02 101.4 99.9 ± 0.22
C3 3200 ± 3.1 153 ± 3.24 0.43 100 0.21 ± 0.06 100.5 96.4 ± 0.74
C4 3200 ± 3.8 151 ± 2.22 0.48 98 0.19 ± 0.04 99.4 98.3 ± 0.65
C5 3652.55 ± 2.5 133 ± 3.54 0.71 72 0.11 ± 0.08 96.7 96.9 ± 0.73
C6 3200 ± 1.0 158 ± 2.63 0.46 96 0.10 ± 0.10 98.4 97.7 ± 0.25
C7 2747.45 ± 1.7 143 ± 2.75 0.55 83 0.21 ± 1.0 99 95.4 ± 0.44
C8 3200 ± 2.9 155 ± 3.08 0.43 101 0.16 ± 0.09 98.5 99.9 ± 0.72
C9 3200 ± 1.7 152 ± 3.08 0.42 102 0.19 ± 1.0 101 92.0 ± 0.33
C10 3840 ± 3.3 123 ± 3.77 0.90 80 0.21 ± 0.08 102.2 95.5 ± 0.43
C11 2560 ± 4.2 127 ± 3.65 0.90 70 0.17 ± 0.02 100.6 98.9 ± 0.53
C12 3200 ± 1.9 142 ± 2.94 0.49 82 0.20 ± 0.04 102.8 98.2 ± 0.22
C13 3200 ± 1.2 154 ± 3.57 0.44 99 0.18 ± 0.07 99.4 97.5 ± 0.41
C14 3200 ± 1.0 128 ± 2.54 0.88 81 0.17 ± 0.07 99 98.4 ± 0.36