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Table 6 Statistical model summary of citric acid and effersoda on hardness

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Source of variation

DF

Adj sum of square

Adj mean square

F value

P value summary

Value

Significant

Model

6

2248.22

374.70

67.26

0.000

Model significant

Linear

2

292.84

146.42

26.28

0.001

Citric acid

1

236.05

236.05

42.37

0.000

Effersoda

1

56.78

56.78

10.19

0.015

Square

2

1851.88

925.94

166.20

0.000

Citric acid (mg)*citric acid (mg)

1

782.17

782.17

140.40

0.000

Effersoda*effersoda

1

1208.32

1208.32

216.89

0.000

2-way interaction

1

100.00

100.00

17.95

0.004

Citric acid (mg)*effersoda

1

100.00

100.00

17.95

0.004

Lack-of-fit

3

8.33

2.78

0.36

0.785

Lack-of-fit not significant

Model summary

S

R-sq

R-sq (adj)

R-sq (pred)

2.36032

98.92%

96.83%

94.00%