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Table 7 Statistical model summary of citric acid and effersoda on friability

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Source of variation DF Adj Sum of square Adj Mean square F value P value summary
Value Significant
Model 6 0.592752 0.098792 119.27 0.000 Model significant
Linear 2 0.150733 0.075367 90.99 0.000
Citric acid 1 0.091740 0.091740 110.75 0.000
Effersoda 1 0.058994 0.058994 71.22 0.000
Square 2 0.395729 0.197865 238.88 0.000
Citric acid (mg)*citric acid (mg) 1 0.150393 0.150393 181.56 0.000
Effersoda*effersoda 1 0.274239 0.274239 331.08 0.000
2-way interaction 1 0.046225 0.046225 55.81 0.000
Citric acid (mg)*effersoda 1 0.046225 0.046225 55.81 0.000
Lack-of-fit 3 0.004332 0.001444 3.94 0.109 Lack-of-fit not significant
Model summary
S R-sq R-sq (adj) R-sq (pred)
0.0287805 99.03% 98.02% 93.92%