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Table 7 Statistical model summary of citric acid and effersoda on friability

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Source of variation

DF

Adj Sum of square

Adj Mean square

F value

P value summary

Value

Significant

Model

6

0.592752

0.098792

119.27

0.000

Model significant

Linear

2

0.150733

0.075367

90.99

0.000

Citric acid

1

0.091740

0.091740

110.75

0.000

Effersoda

1

0.058994

0.058994

71.22

0.000

Square

2

0.395729

0.197865

238.88

0.000

Citric acid (mg)*citric acid (mg)

1

0.150393

0.150393

181.56

0.000

Effersoda*effersoda

1

0.274239

0.274239

331.08

0.000

2-way interaction

1

0.046225

0.046225

55.81

0.000

Citric acid (mg)*effersoda

1

0.046225

0.046225

55.81

0.000

Lack-of-fit

3

0.004332

0.001444

3.94

0.109

Lack-of-fit not significant

Model summary

S

R-sq

R-sq (adj)

R-sq (pred)

0.0287805

99.03%

98.02%

93.92%