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Table 8 Statistical model summary of citric acid and effersoda on effervescent time

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Source of variation DF Adj sum of square Adj mean square F value P value summary
Value Significant
Model 6 1945.25 324.21 59.44 0.000 Model significant
Linear 2 37.51 18.76 3.44 0.091
Citric acid 1 2.83 2.83 0.52 0.495
Effersoda 1 34.68 34.68 6.36 0.040
Square 2 1842.35 921.17 168.89 0.000
Citric acid (mg)*citric acid (mg) 1 507.71 507.71 93.08 0.000
Effersoda*effersoda 1 1456.01 1456.01 266.95 0.000
2-way interaction 1 42.25 42.25 7.75 0.027
Citric acid (mg)*effersoda 1 42.25 42.25 7.75 0.027
Lack-of-fit 3 25.51 8.50 2.69 0.182 Lack-of-fit not significant
Model Summary
S R-sq R-sq (adj) R-sq (pred)
2.33544 98.08% 96.43% 84.95%