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Table 8 Statistical model summary of citric acid and effersoda on effervescent time

From: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam

Source of variation

DF

Adj sum of square

Adj mean square

F value

P value summary

Value

Significant

Model

6

1945.25

324.21

59.44

0.000

Model significant

Linear

2

37.51

18.76

3.44

0.091

Citric acid

1

2.83

2.83

0.52

0.495

Effersoda

1

34.68

34.68

6.36

0.040

Square

2

1842.35

921.17

168.89

0.000

Citric acid (mg)*citric acid (mg)

1

507.71

507.71

93.08

0.000

Effersoda*effersoda

1

1456.01

1456.01

266.95

0.000

2-way interaction

1

42.25

42.25

7.75

0.027

Citric acid (mg)*effersoda

1

42.25

42.25

7.75

0.027

Lack-of-fit

3

25.51

8.50

2.69

0.182

Lack-of-fit not significant

Model Summary

S

R-sq

R-sq (adj)

R-sq (pred)

2.33544

98.08%

96.43%

84.95%