Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

Future Journal of Pharmaceutical Sciences

Table 2 Anxiolytic activity of different extract of A. trilobata on hole-board test in mice

Group (mg/kg)	No. of head dipping	Latency of first head dipping (s)
Control	26.33 ± 0.88	8.33 ± 0.88
Diazepam (1)	64.33 ± 3.16^c	2.0 ± 0.57^a
MEATL 200	39.33 ± 2.33^b	6.33 ± 2.40^ns
MEATL 400	51.67 ± 0.88^c	5.67 ± 0.88^ns
NFATL 200	43.0 ± 2.89^c	5.67 ± 1.76^ns
NFATL 400	57.67 ± 3.18^c	5.33 ± 1.76^ns
MEATS 200	31.0 ± 1.53^ns	8.0 ± 2.65^ns
MEATS 400	40.33 ± 2.33^c	7.0 ± 1.53^ns
NFATS 200	34.67 ± 0.88^ns	7.53 ± 0.33^ns
NFATS 400	46.33 ± 1.86^c	4.67 ± 0.45^ns

ns non-significant, MEATL methanol extract of A. trilobata leaves, NFATL n-hexane fraction of A. trilobata leaves, MEATS methanol extract of A. trilobata stem, NFATS n-hexane fraction of A. trilobata stem
The results were expressed in mean ± SEM (standard error mean)
^ap < 0.05 considered as statistically significant
^bp < 0.01 considered as statistically significant
^cp < 0.001 considered as statistically significant