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Future Journal of Pharmaceutical Sciences

Table 3 Antidepressant activity of different extracts of A. trilobata on forced swimming test in mice

From: Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

Group (mg/kg)

Immobile time

Inhibition (%)

Control (10 mL/kg)

194.67 ± 2.91

-

Fluoxetine (20)

88.0 ± 1.15c

54.79

MEATL 200

183.0 ± 6.51ns

5.99

MEATL 400

135.33 ± 2.91c

30.48

NFATL 200

159.0 ± 4.73c

18.32

NFATL 400

110.33 ± 4.06c

43.32

MEATS 200

161.67 ± 4.91c

16.95

MEATS 400

130.0 ± 3.61c

30.22

NFATS 200

169.33 ± 1.76c

13.01

NFATS 400

117.33 ± 3.84c

39.73

  1. ns non-significant, MEATL methanol extract of A. trilobata leaves, NFATL n-hexane fraction of A. trilobata leaves, MEATS methanol extract of A. trilobata stem, NFATS n-hexane fraction of A. trilobata stem
  2. The statistical analysis followed by one-way analysis of variance (Dunnett’s test) compared to the negative control (1% Tween-80) using GraphPad Prism version 8.4
  3. The results were expressed in mean ± SEM (standard error mean)
  4. cp < 0.001 considered as statistically significant
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