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Table 3 Antidepressant activity of different extracts of A. trilobata on forced swimming test in mice

From: Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

Group (mg/kg) Immobile time Inhibition (%)
Control (10 mL/kg) 194.67 ± 2.91 -
Fluoxetine (20) 88.0 ± 1.15c 54.79
MEATL 200 183.0 ± 6.51ns 5.99
MEATL 400 135.33 ± 2.91c 30.48
NFATL 200 159.0 ± 4.73c 18.32
NFATL 400 110.33 ± 4.06c 43.32
MEATS 200 161.67 ± 4.91c 16.95
MEATS 400 130.0 ± 3.61c 30.22
NFATS 200 169.33 ± 1.76c 13.01
NFATS 400 117.33 ± 3.84c 39.73
  1. ns non-significant, MEATL methanol extract of A. trilobata leaves, NFATL n-hexane fraction of A. trilobata leaves, MEATS methanol extract of A. trilobata stem, NFATS n-hexane fraction of A. trilobata stem
  2. The statistical analysis followed by one-way analysis of variance (Dunnett’s test) compared to the negative control (1% Tween-80) using GraphPad Prism version 8.4
  3. The results were expressed in mean ± SEM (standard error mean)
  4. cp < 0.001 considered as statistically significant