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Table 3 Coefficient and P value for full model for variables in the 32 full factorial design

From: Study of homogenization on media milling time in preparation of irbesartan nanosuspension and optimization using design of experiments (DoE)

Term

Y1

P value

Y2

P value

X1

30.1667

0.000332

− 3.23

1.03E−05

X2

− 89.83333

1.27E−05

12.63

0.014

X1X2

9

0.019728

− 0.22

0.00028

X12

4.5

0.205026

0.12

0.796

X22

18.5

0.006979

− 4.13

0.918

R2 value

0.999

 

R2 value

0.993