Table 1 Recently isolated lycodine type Lycopodium alkaloids and theiracetylcholinesterase (AChE) inhibitory activity
From: Recently isolated lycodine-type Lycopodium alkaloids and their total synthesis: a review
Lycopodium alkaloid | Plant spp. | LC50 | Reference |
|---|---|---|---|
Complanadine A (2) | Lycopodium complanatum | – | [14] |
Himeradine A (3) | Lycopodium chinense | – | [15] |
Huperzinine N-oxide (4) | Lycopodium casuarinoides | – | [16] |
8,15-dihydrohuperzinine (5) | – | ||
N-demethyl-obscurine (6) | Lycopodium serratum | – | [17] |
Lycodine (1) | – | ||
Casuarine A (7) | Lycopodium casuarinoides | – | [18] |
Casuarine B (8) | 46.4 μM | ||
N-demethyl-sauroxine (9) | Huperziasaururus | – | [19] |
N-methylhydroxypropyllycodine (10) | Lycopodium japonicum | – | [20] |
Huperserine E (11) | Huperzia serrata | 6.71 μM | [21] |
8,15-dihydrohuperzine A (12) | Huperziacarinata | 2.6 μM | [22] |
16-hydroxyhuperzine B (13) | Lycopodiastrumcasuarinoides | 87.3 μM | [23] |
N-methyl-11-acetoxyhuperzine B (14) | – | ||
8,15-dihydrolycoparin A (15) | – | ||
(7S,12S, 13R)-huperzine D-16-O-β-D-glucopyranoside (16) | – | ||
N-demethylhuperzinine (17) | 1.9 μM | ||
Lycoparin C (18) | 23.9 μM | ||
N-methylhydroxypropyllycodine (10) | Lycopodium japonicum | – | [24] |
Phlefargesiine A (19) | Phlegmariurusfargesii | – | [25] |
16-hydroxylycodine (20) | Phlegmariurushenryi | – | [26] |
Lycocasuarine A (21) | Lycopodiastrum casuarinoides | > 100 μM | [27] |
Lycocasuarine B (22) | > 100 μM | ||
Lycocasuarine C (23) | 7.4 μM | ||
lycoannotine G (24) | Lycopodium annotinum | – | [28] |
lycoannotine H (25) | – | ||
Lycofargesiine A (26) | Huperziafargesii | – | [29] |
Lycofargesiine B (27) | – | ||
Lycofargesiine C (28) | 8.63 μM | ||
Lycofargesiine D (29) | – | ||
12α-hydroxy-N-demethyl-sauroxine (30) | Phlegmariurussaururus | 33.8 μM | [30] |
N-methyllycodine (31) | 547.5 μM | ||
N-demethyl-sauroxine (9) | 1.38 μM | ||
Lycocasuarine I (32) | Lycopodiastrum casuarinoides | > 200 μM | [31] |
Lycocasuarine J (33) | > 200 μM | ||
Lycocasuarine K (34) | 171.9 μM | ||
Lycocasuarine L (35) | > 200 μM | ||
Lycocasuarine M (36) | 97.2 μM | ||
Lycocasuarine N (37) | 112.1 μM | ||
Lycocasuarine O (38) | 137.8 μM | ||
Lycocasuarine P (39) | 127.8 μM | ||
Lycocasuarine Q (40) | > 200 μM | ||
Lycoplatyrine A (41) | Lycopodium platyrhizoma | > 30 μM | [32] |
Lycoplatyrine B (42) | > 30 μM | ||
Lycoplanine D (43) | – |